Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 721836..722473 Replicon chromosome
Accession NZ_CP048751
Organism Brevundimonas mediterranea strain D151-2-6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GYM46_RS03600 Protein ID WP_154726295.1
Coordinates 721836..722255 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GYM46_RS03605 Protein ID WP_196066381.1
Coordinates 722252..722473 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYM46_RS03575 717548..718567 + 1020 WP_008259271.1 glycosyltransferase family 4 protein -
GYM46_RS03580 718666..720231 + 1566 WP_040349272.1 alkaline phosphatase D family protein -
GYM46_RS03585 720290..720646 + 357 WP_008259953.1 type II toxin-antitoxin system RelE/ParE family toxin -
GYM46_RS03590 720648..720968 + 321 WP_008264199.1 XRE family transcriptional regulator -
GYM46_RS03595 721018..721839 - 822 WP_008261349.1 YmdB family metallophosphoesterase -
GYM46_RS03600 721836..722255 - 420 WP_154726295.1 type II toxin-antitoxin system VapC family toxin Toxin
GYM46_RS03605 722252..722473 - 222 WP_196066381.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GYM46_RS03610 722517..723074 - 558 WP_008264368.1 5-formyltetrahydrofolate cyclo-ligase -
GYM46_RS03620 723466..723786 - 321 WP_008263136.1 cell division protein ZapA -
GYM46_RS03625 723786..724064 - 279 WP_008263869.1 hypothetical protein -
GYM46_RS03630 724161..726152 + 1992 WP_008262676.1 transketolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(6-53)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15476.65 Da        Isoelectric Point: 6.6446

>T149950 WP_154726295.1 NZ_CP048751:c722255-721836 [Brevundimonas mediterranea]
VTGFMLDTSICIEILRGRSAALNDRLKSEQAPLHVSTVVVMELAVGPNKLADPRRRDLLEAFLARLEILPFDEDAARHTA
EIRAVLERQGRPIGPYDYQIAGHARSQGLTVVTRNIGEFERVAGLRVEHWSDPSKGVHE

Download         Length: 420 bp

>T149950 NZ_CP064352:c3567279-3566995 [Klebsiella pneumoniae subsp. pneumoniae ATCC 43816]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.81 Da        Isoelectric Point: 8.7129

>AT149950 WP_196066381.1 NZ_CP048751:c722473-722252 [Brevundimonas mediterranea]
MKATVFKSNRSQAVRLPKAAAFPDDVKELRVIKEGKSLRLVPVNALWDDFFDRPGIPDWPDRDQPEMQKREEW

Download         Length: 222 bp

>AT149950 NZ_CP064352:c3567511-3567269 [Klebsiella pneumoniae subsp. pneumoniae ATCC 43816]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References