Detailed information of TA system TA149950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 721836..722473
• Replicon: chromosome
• Accession: NZ_CP048751
• Organism: Brevundimonas mediterranea strain D151-2-6

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GYM46_RS03600
• Protein ID: WP_154726295.1
• Coordinates: 721836..722255 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GYM46_RS03605
• Protein ID: WP_196066381.1
• Coordinates: 722252..722473 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GYM46_RS03575	717548..718567	+	1020	WP_008259271.1	glycosyltransferase family 4 protein	-
GYM46_RS03580	718666..720231	+	1566	WP_040349272.1	alkaline phosphatase D family protein	-
GYM46_RS03585	720290..720646	+	357	WP_008259953.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GYM46_RS03590	720648..720968	+	321	WP_008264199.1	XRE family transcriptional regulator	-
GYM46_RS03595	721018..721839	-	822	WP_008261349.1	YmdB family metallophosphoesterase	-
GYM46_RS03600	721836..722255	-	420	WP_154726295.1	type II toxin-antitoxin system VapC family toxin	Toxin
GYM46_RS03605	722252..722473	-	222	WP_196066381.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GYM46_RS03610	722517..723074	-	558	WP_008264368.1	5-formyltetrahydrofolate cyclo-ligase	-
GYM46_RS03620	723466..723786	-	321	WP_008263136.1	cell division protein ZapA	-
GYM46_RS03625	723786..724064	-	279	WP_008263869.1	hypothetical protein	-
GYM46_RS03630	724161..726152	+	1992	WP_008262676.1	transketolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

• SpoVT-AbrB domain (6-53)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15476.65 Da
• Isoelectric Point: 6.6446

>T149950 WP_154726295.1 NZ_CP048751:c722255-721836 [Brevundimonas mediterranea]
VTGFMLDTSICIEILRGRSAALNDRLKSEQAPLHVSTVVVMELAVGPNKLADPRRRDLLEAFLARLEILPFDEDAARHTA
EIRAVLERQGRPIGPYDYQIAGHARSQGLTVVTRNIGEFERVAGLRVEHWSDPSKGVHE

Nucleotide

• Length: 420 bp

>T149950 NZ_CP064352:c3567279-3566995 [Klebsiella pneumoniae subsp. pneumoniae ATCC 43816]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8566.81 Da
• Isoelectric Point: 8.7129

>AT149950 WP_196066381.1 NZ_CP048751:c722473-722252 [Brevundimonas mediterranea]
MKATVFKSNRSQAVRLPKAAAFPDDVKELRVIKEGKSLRLVPVNALWDDFFDRPGIPDWPDRDQPEMQKREEW

Nucleotide

• Length: 222 bp

>AT149950 NZ_CP064352:c3567511-3567269 [Klebsiella pneumoniae subsp. pneumoniae ATCC 43816]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA