Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3897462..3898119 Replicon chromosome
Accession NZ_CP048736
Organism Enterobacter sp. T2

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag G0034_RS18675 Protein ID WP_014885136.1
Coordinates 3897462..3897872 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag G0034_RS18680 Protein ID WP_010435322.1
Coordinates 3897853..3898119 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0034_RS18655 (3893456) 3893456..3895189 - 1734 WP_032635612.1 single-stranded-DNA-specific exonuclease RecJ -
G0034_RS18660 (3895195) 3895195..3895908 - 714 WP_014885133.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G0034_RS18665 (3895937) 3895937..3896833 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
G0034_RS18670 (3896935) 3896935..3897456 + 522 WP_071922917.1 flavodoxin FldB -
G0034_RS18675 (3897462) 3897462..3897872 - 411 WP_014885136.1 protein YgfX Toxin
G0034_RS18680 (3897853) 3897853..3898119 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
G0034_RS18685 (3898414) 3898414..3899394 + 981 WP_014885137.1 tRNA-modifying protein YgfZ -
G0034_RS18690 (3899479) 3899479..3900138 - 660 WP_023331242.1 hemolysin III family protein -
G0034_RS18695 (3900404) 3900404..3901135 + 732 WP_179121345.1 MurR/RpiR family transcriptional regulator -
G0034_RS18700 (3901252) 3901252..3902685 + 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T149945 WP_014885136.1 NZ_CP048736:c3897872-3897462 [Enterobacter sp. T2]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T149945 NZ_CP064352:c593120-592704 [Klebsiella pneumoniae subsp. pneumoniae ATCC 43816]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGGGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCACCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTACCGGGCCTGGTGCTGG
AAGACTGGGTAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT149945 WP_010435322.1 NZ_CP048736:c3898119-3897853 [Enterobacter sp. T2]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT149945 NZ_CP064352:c593347-593117 [Klebsiella pneumoniae subsp. pneumoniae ATCC 43816]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGTGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References