Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1083534..1084154 Replicon chromosome
Accession NZ_CP048736
Organism Enterobacter sp. T2

Toxin (Protein)


Gene name Hha Uniprot ID A0A2W0G488
Locus tag G0034_RS05105 Protein ID WP_014882802.1
Coordinates 1083534..1083752 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag G0034_RS05110 Protein ID WP_008499288.1
Coordinates 1083780..1084154 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0034_RS05075 (1079543) 1079543..1079803 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
G0034_RS05080 (1079806) 1079806..1079946 + 141 WP_179121310.1 type B 50S ribosomal protein L36 -
G0034_RS05085 (1079943) 1079943..1080653 - 711 WP_179120571.1 GNAT family protein -
G0034_RS05090 (1080755) 1080755..1082215 + 1461 WP_179120572.1 PLP-dependent aminotransferase family protein -
G0034_RS05095 (1082187) 1082187..1082654 - 468 WP_179120573.1 YlaC family protein -
G0034_RS05100 (1082773) 1082773..1083324 - 552 WP_014882801.1 maltose O-acetyltransferase -
G0034_RS05105 (1083534) 1083534..1083752 - 219 WP_014882802.1 HHA domain-containing protein Toxin
G0034_RS05110 (1083780) 1083780..1084154 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
G0034_RS05115 (1084666) 1084666..1087812 - 3147 WP_014882803.1 multidrug efflux RND transporter permease subunit AcrB -
G0034_RS05120 (1087835) 1087835..1089028 - 1194 WP_014882804.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T149934 WP_014882802.1 NZ_CP048736:c1083752-1083534 [Enterobacter sp. T2]
MSEKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T149934 NZ_CP064351:436126-436413 [Vibrio cholerae C6706]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT149934 WP_008499288.1 NZ_CP048736:c1084154-1083780 [Enterobacter sp. T2]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT149934 NZ_CP064351:436424-436741 [Vibrio cholerae C6706]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G488

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References