Detailed information of TA system TA149932

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 456725..457320
• Replicon: chromosome
• Accession: NZ_CP048736
• Organism: Enterobacter sp. T2

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: G0034_RS02180
• Protein ID: WP_032637645.1
• Coordinates: 456970..457320 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: A0A8B2XPR3
• Locus tag: G0034_RS02175
• Protein ID: WP_032637647.1
• Coordinates: 456725..456976 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0034_RS02165 (452392)	452392..456168	+	3777	WP_179120454.1	autotransporter assembly complex protein TamB	-
G0034_RS02170 (456171)	456171..456515	+	345	WP_014882267.1	gamma-glutamylcyclotransferase	-
G0034_RS02175 (456725)	456725..456976	+	252	WP_032637647.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
G0034_RS02180 (456970)	456970..457320	+	351	WP_032637645.1	type II toxin-antitoxin system ChpB family toxin	Toxin
G0034_RS02185 (457398)	457398..457928	-	531	WP_008501423.1	inorganic diphosphatase	-
G0034_RS02190 (458238)	458238..459194	+	957	WP_047626912.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
G0034_RS02195 (459297)	459297..460799	+	1503	WP_045134407.1	sugar ABC transporter ATP-binding protein	-
G0034_RS02200 (460810)	460810..461835	+	1026	WP_014882273.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• Antitoxin PemI-like (1-83)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12354.33 Da
• Isoelectric Point: 6.9493

>T149932 WP_032637645.1 NZ_CP048736:456970-457320 [Enterobacter sp. T2]
MVKRPCFERGDIVLVGFDPANGHEQKGAGRPALVLSVSAFNQLGMTLVAPVTQGGNFARYAGFSVPLSCEEGNIQGVILV
NQIRMMDLGARLAKRIGVASDETVEDALLRLQAILS

Nucleotide

• Length: 351 bp

>T149932 NZ_CP064351:c416628-416329 [Vibrio cholerae C6706]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9032.36 Da
• Isoelectric Point: 4.2517

>AT149932 WP_032637647.1 NZ_CP048736:456725-456976 [Enterobacter sp. T2]
MRITIKKWGNSAGMVIPGVVMKELGLKPGQSMEAQVTNNQLVLTPVSKQYSLEELLAQCDMSAPEINEQDAWGTSGPVGD
EVW

Nucleotide

• Length: 252 bp

>AT149932 NZ_CP064351:c416867-416625 [Vibrio cholerae C6706]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A8B2XPR3