Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1024900..1025417 Replicon chromosome
Accession NZ_CP048713
Organism Staphylococcus lugdunensis strain CGMH-SL138

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag G3G86_RS04745 Protein ID WP_002461192.1
Coordinates 1025067..1025417 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag G3G86_RS04740 Protein ID WP_002461193.1
Coordinates 1024900..1025070 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3G86_RS04715 1020725..1021207 + 483 WP_002492078.1 PH domain-containing protein -
G3G86_RS04720 1021200..1022714 + 1515 WP_002492082.1 PH domain-containing protein -
G3G86_RS04725 1022701..1023213 + 513 WP_002461197.1 PH domain-containing protein -
G3G86_RS04730 1023225..1023617 + 393 WP_002461196.1 holo-ACP synthase -
G3G86_RS04735 1023665..1024813 + 1149 WP_002492086.1 alanine racemase -
G3G86_RS04740 1024900..1025070 + 171 WP_002461193.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
G3G86_RS04745 1025067..1025417 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G3G86_RS04750 1025850..1026851 + 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
G3G86_RS04755 1026942..1027268 + 327 WP_002461190.1 anti-sigma factor antagonist -
G3G86_RS04760 1027270..1027749 + 480 WP_037540680.1 anti-sigma B factor RsbW -
G3G86_RS04765 1027724..1028494 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T149923 WP_002461192.1 NZ_CP048713:1025067-1025417 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T149923 NZ_CP064343:192964-193230 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT149923 WP_002461193.1 NZ_CP048713:1024900-1025070 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT149923 NZ_CP064343:192701-192964 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References