Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1013502..1014020 Replicon chromosome
Accession NZ_CP048713
Organism Staphylococcus lugdunensis strain CGMH-SL138

Toxin (Protein)


Gene name TsdT Uniprot ID A0A853V532
Locus tag G3G86_RS04685 Protein ID WP_002492077.1
Coordinates 1013808..1014020 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A853V130
Locus tag G3G86_RS04680 Protein ID WP_002492098.1
Coordinates 1013502..1013795 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3G86_RS04660 1009102..1009740 + 639 WP_002492090.1 thiamine phosphate synthase -
G3G86_RS04665 1009830..1010705 + 876 WP_002461212.1 membrane protein insertase YidC -
G3G86_RS04670 1011089..1011730 - 642 WP_002492092.1 HD domain-containing protein -
G3G86_RS04675 1011852..1013336 - 1485 WP_002478972.1 cardiolipin synthase -
G3G86_RS04680 1013502..1013795 + 294 WP_002492098.1 copper-sensing transcriptional repressor CsoR Antitoxin
G3G86_RS04685 1013808..1014020 + 213 WP_002492077.1 heavy metal-associated domain-containing protein Toxin
G3G86_RS04690 1014111..1014248 + 138 WP_002461206.1 Lmo0850 family protein -
G3G86_RS04695 1014662..1015852 - 1191 WP_002461205.1 FtsW/RodA/SpoVE family cell cycle protein -
G3G86_RS04700 1016208..1017278 + 1071 WP_002461204.1 D-alanine--D-alanine ligase -
G3G86_RS04705 1017296..1018654 + 1359 WP_002492089.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-90)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8087.02 Da        Isoelectric Point: 3.9947

>T149922 WP_002492077.1 NZ_CP048713:1013808-1014020 [Staphylococcus lugdunensis]
VEKRLIYITNVTNEDDLENLRTRLLEMIGVNEVVINFDERAVNVTFETSTNLNALEKEIYDAGYHAIDDL

Download         Length: 213 bp

>T149922 NZ_CP064334:c2526504-2526205 [Xylella fastidiosa subsp. fastidiosa]
ATGACCTACACGCTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGCGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTAGAGGATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11177.85 Da        Isoelectric Point: 6.6367

>AT149922 WP_002492098.1 NZ_CP048713:1013502-1013795 [Staphylococcus lugdunensis]
MNEQDHAHHSKIVKANLKSRLNRIEGQVRAINRMVEDDVYCDDVLTQIRATRSALTSVATKLLEHHMKSCIMDKINDGQE
VEAMEELLVTFQKMLKD

Download         Length: 294 bp

>AT149922 NZ_CP064334:c2526201-2525893 [Xylella fastidiosa subsp. fastidiosa]
GTGACCATCACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTTGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCCCTTCGGCCTGGTAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V532

Antitoxin

Source ID Structure
AlphaFold DB A0A853V130

References