Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4126046..4126698 Replicon chromosome
Accession NZ_CP048711
Organism Kineobactrum salinum strain M2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G3T16_RS18225 Protein ID WP_197912057.1
Coordinates 4126046..4126435 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G3T16_RS18230 Protein ID WP_163496468.1
Coordinates 4126456..4126698 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3T16_RS18190 4122061..4122537 + 477 WP_163496462.1 hypothetical protein -
G3T16_RS18195 4122634..4123218 + 585 WP_163496463.1 hypothetical protein -
G3T16_RS18200 4123342..4123703 + 362 Protein_3648 DUF3127 domain-containing protein -
G3T16_RS18205 4123718..4123975 - 258 WP_163496464.1 type II toxin-antitoxin system RelE/ParE family toxin -
G3T16_RS18210 4123962..4124195 - 234 WP_163496465.1 CopG family transcriptional regulator -
G3T16_RS18215 4124427..4124654 - 228 WP_163496466.1 hypothetical protein -
G3T16_RS21330 4124780..4125322 + 543 WP_197911745.1 DUF3524 domain-containing protein -
G3T16_RS21335 4125274..4125924 + 651 WP_197911746.1 hypothetical protein -
G3T16_RS18225 4126046..4126435 - 390 WP_197912057.1 type II toxin-antitoxin system VapC family toxin Toxin
G3T16_RS18230 4126456..4126698 - 243 WP_163496468.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
G3T16_RS18235 4126812..4127582 + 771 WP_163496469.1 alpha/beta hydrolase -
G3T16_RS18240 4127730..4127882 + 153 WP_197912058.1 DUF3309 domain-containing protein -
G3T16_RS18245 4127865..4129475 - 1611 WP_163496471.1 50S ribosome-binding GTPase -
G3T16_RS18250 4129468..4130604 - 1137 WP_163496472.1 GTP-binding DUF697 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

SpoVT-AbrB domain

(11-52)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13820.87 Da        Isoelectric Point: 5.5791

>T149919 WP_197912057.1 NZ_CP048711:c4126435-4126046 [Kineobactrum salinum]
MDTNMLSDLVRNPHGTVADRIAAIGEDSVCTSIVVAVELRYGAAKSGSEKLAGRIDLLLSAIEVLPLEAPVDRRYAELRH
HLTRQGTPIGPNDLLICAHALAAGLTVVTANVGEFSRVPGLKVENWLQE

Download         Length: 390 bp

>T149919 NZ_CP064334:1408891-1409157 [Xylella fastidiosa subsp. fastidiosa]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAGCTCGACAAGCACATGGCGCGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAACCCACGCAGCAGTGGTAAAGCATTAACCGGACCACTTGGCGGCT
TTTGGCGTTATCGTGTTGGTGATTTCCGGGTCGTCTGCGCCATTCAAGATAGCGTTTTGCGCGTCCTTGTAGTGCGTGTT
GGTCACCGGGGTGAGATTTACCGATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9185.47 Da        Isoelectric Point: 4.7010

>AT149919 WP_163496468.1 NZ_CP048711:c4126698-4126456 [Kineobactrum salinum]
MTTSERHVRLFRNGRNQALRIPREFELEGTEALIHKEGDRLIVEPVRKGRLLAILSSLEPLDEPFPDVDEDLPPLDDKAL

Download         Length: 243 bp

>AT149919 NZ_CP064334:1408680-1408907 [Xylella fastidiosa subsp. fastidiosa]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTGAACTCTCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTACGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTGTTGGAACGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGATGTGAGGAAAACGCTTGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References