Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4103885..4104542 Replicon chromosome
Accession NZ_CP048696
Organism Enterobacter hormaechei strain Eho-E4

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag GVI76_RS19945 Protein ID WP_017382887.1
Coordinates 4103885..4104295 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag GVI76_RS19950 Protein ID WP_003863437.1
Coordinates 4104276..4104542 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI76_RS19925 4099883..4101616 - 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -
GVI76_RS19930 4101622..4102335 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GVI76_RS19935 4102364..4103260 - 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
GVI76_RS19940 4103362..4103883 + 522 WP_015571793.1 flavodoxin FldB -
GVI76_RS19945 4103885..4104295 - 411 WP_017382887.1 protein YgfX Toxin
GVI76_RS19950 4104276..4104542 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
GVI76_RS19955 4104837..4105817 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
GVI76_RS19960 4105929..4106588 - 660 WP_003863433.1 hemolysin III family protein -
GVI76_RS19965 4106855..4107586 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
GVI76_RS19970 4107703..4109136 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T149913 WP_017382887.1 NZ_CP048696:c4104295-4103885 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T149913 NZ_CP064334:457981-458283 [Xylella fastidiosa subsp. fastidiosa]
ATGGAGAAAGGCACATCTCACTATAAGCTACCAGTCGTCAAAGCCTTGGTGAAAGCTGGCAAGGTCAGGGCTACAGCGAC
CGCCTACCAAGGAGCACGTGAGCTCGGCATCAAAGATTTAACTGGAATGTGCACCGTTGTCTTGGCGCTCACGTCTGCCG
ACTTCTACAAGAGCATGACGACCTACGCGGATCACACAGTATTCCAGGATGTGTACCACGCCAAGACGGCAAGCGGTGAT
GAGGTGTACCTGAAGTTAACTGTCATTGATGACGTGTTGATTGTTTCCTTCAAGGAGTTATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT149913 WP_003863437.1 NZ_CP048696:c4104542-4104276 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT149913 NZ_CP064334:457618-457893 [Xylella fastidiosa subsp. fastidiosa]
ATGAAACGTATGCACAATCCCGCACATCCAGGTGAAGTGTTGCGTGAGTATCTTGGTGAGCTCACTGTGACCAATGCGGC
TGCAAAGCTAGGCGTCAGCCGTGTGGCTTTGTCGCGTATTCTCAATGGTACCAATGGCATCTCTGCCGATATGGCCCTTC
GCCTGGAAGATGCGCTTGGCACCAGTGCAGAGATGTGGGCAGCCATGCAGTTCAAGTATGACCTGTGGGTTGCTAGTCAG
CAGCCACGCCCGAAGATCACGCGCCTTCATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References