Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3081450..3082055 Replicon chromosome
Accession NZ_CP048696
Organism Enterobacter hormaechei strain Eho-E4

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag GVI76_RS14850 Protein ID WP_012906750.1
Coordinates 3081450..3081629 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A822X3T2
Locus tag GVI76_RS14855 Protein ID WP_032619507.1
Coordinates 3081651..3082055 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI76_RS14825 3076779..3077495 + 717 WP_032619512.1 ABC transporter ATP-binding protein -
GVI76_RS14830 3077661..3078131 + 471 WP_017384432.1 hypothetical protein -
GVI76_RS14835 3078137..3079063 - 927 WP_032619511.1 LysR family transcriptional regulator -
GVI76_RS14840 3079093..3079416 - 324 WP_017384434.1 hypothetical protein -
GVI76_RS14845 3079419..3080174 - 756 Protein_2909 DUF4225 domain-containing protein -
GVI76_RS14850 3081450..3081629 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
GVI76_RS14855 3081651..3082055 + 405 WP_032619507.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GVI76_RS14860 3082096..3083166 - 1071 WP_032635096.1 glycosyltransferase family 9 protein -
GVI76_RS14865 3083243..3083821 - 579 WP_032619505.1 tail fiber assembly protein -
GVI76_RS14870 3083821..3085998 - 2178 WP_058670599.1 phage tail protein -
GVI76_RS14875 3086001..3086552 - 552 WP_032619504.1 phage tail protein I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliA 3076791..3186465 109674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T149910 WP_012906750.1 NZ_CP048696:3081450-3081629 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T149910 NZ_CP064332:c2526812-2526504 [Xylella fastidiosa subsp. fastidiosa]
GTGACCATCACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTTGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCCCTTCGGCCTGGTAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14676.53 Da        Isoelectric Point: 4.2136

>AT149910 WP_032619507.1 NZ_CP048696:3081651-3082055 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGEDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVINQR

Download         Length: 405 bp

>AT149910 NZ_CP064332:c2527115-2526816 [Xylella fastidiosa subsp. fastidiosa]
ATGACCTACACGCTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGCGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTAGAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A822X3T2

References