Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2606274..2607013 Replicon chromosome
Accession NZ_CP048696
Organism Enterobacter hormaechei strain Eho-E4

Toxin (Protein)


Gene name tacT Uniprot ID A0A822W909
Locus tag GVI76_RS12615 Protein ID WP_017382345.1
Coordinates 2606274..2606759 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag GVI76_RS12620 Protein ID WP_003857131.1
Coordinates 2606747..2607013 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI76_RS12590 2601850..2602434 - 585 WP_017382349.1 GDP-mannose pyrophosphatase nudK -
GVI76_RS12595 2602521..2603279 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
GVI76_RS12600 2603384..2604676 + 1293 WP_023303742.1 hypothetical protein -
GVI76_RS12605 2604676..2605290 + 615 WP_023303743.1 NUDIX hydrolase -
GVI76_RS12610 2605654..2606223 + 570 WP_017382346.1 hypothetical protein -
GVI76_RS12615 2606274..2606759 - 486 WP_017382345.1 GNAT family N-acetyltransferase Toxin
GVI76_RS12620 2606747..2607013 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
GVI76_RS12625 2607077..2608006 - 930 WP_023303744.1 LysR family transcriptional regulator -
GVI76_RS12630 2608136..2609524 + 1389 WP_032619651.1 MFS transporter -
GVI76_RS12635 2609546..2610541 - 996 WP_023303746.1 DUF2891 domain-containing protein -
GVI76_RS12640 2610551..2611537 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17510.21 Da        Isoelectric Point: 9.9658

>T149901 WP_017382345.1 NZ_CP048696:c2606759-2606274 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARAFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T149901 NZ_CP064332:457383-457664 [Xylella fastidiosa subsp. fastidiosa]
ATGATCAAAAGTTTCCGCCACAAAGGCATTCAACAATTCTTCCTCAAGGGATCAACCGCTGGTATCCAAACCAAACACGC
CGCCAAACTGCGTATCCAGCTCACCGCGTTGGAGAGTGCCAAGCGCCCCGAAGATATGAATGCTCCAGGCTGGAAACTGC
ACCCACTAAAAGGCGCTGACTTAAAAGGTCATTGGTCCATCTGGGTGAATGGCAACTATCGCCTCACGTTTGCTTTTGAA
GGCGAAGACGCAATCTTGGTCGACTATCAGGATTATCACTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT149901 WP_003857131.1 NZ_CP048696:c2607013-2606747 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT149901 NZ_CP064332:457675-457950 [Xylella fastidiosa subsp. fastidiosa]
ATGAAACGTATGCACAATCCCGCACATCCAGGTGAAGTGTTGCGTGAGTATCTTGGTGAGCTCACTGTGACCAATGCGGC
TGCAAAGCTAGGCGTCAGCCGTGTGGCTTTGTCGCGTATTCTCAATGGTACCAATGGCATCTCTGCCGATATGGCCCTTC
GCCTGGAAGATGCGCTTGGCACCAGTGCAGAGATGTGGGCAGCCATGCAGTTCAAGTATGACCTGTGGGTTGCTAGTCAG
CAGCCACGCCCGAAGATCACGCGCCTTCATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822W909

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References