Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1383979..1384599 Replicon chromosome
Accession NZ_CP048696
Organism Enterobacter hormaechei strain Eho-E4

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag GVI76_RS06660 Protein ID WP_015571250.1
Coordinates 1383979..1384197 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag GVI76_RS06665 Protein ID WP_006809850.1
Coordinates 1384225..1384599 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI76_RS06630 1379991..1380251 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
GVI76_RS06635 1380254..1380394 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GVI76_RS06640 1380391..1381101 - 711 WP_023303201.1 GNAT family N-acetyltransferase -
GVI76_RS06645 1381203..1382663 + 1461 WP_032620143.1 PLP-dependent aminotransferase family protein -
GVI76_RS06650 1382635..1383102 - 468 WP_017383209.1 membrane protein -
GVI76_RS06655 1383219..1383770 - 552 WP_023303203.1 maltose O-acetyltransferase -
GVI76_RS06660 1383979..1384197 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
GVI76_RS06665 1384225..1384599 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
GVI76_RS06670 1385110..1388256 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
GVI76_RS06675 1388279..1389472 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T149900 WP_015571250.1 NZ_CP048696:c1384197-1383979 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T149900 NZ_CP064330:c2509898-2509599 [Xylella fastidiosa subsp. fastidiosa]
ATGACCTACACGCTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGCGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTAGAGGATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT149900 WP_006809850.1 NZ_CP048696:c1384599-1384225 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT149900 NZ_CP064330:c2509595-2509287 [Xylella fastidiosa subsp. fastidiosa]
GTGACCATCACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTTGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCCCTTCGGCCTGGTAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References