Detailed information of TA system TA149897

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 198866..199415
• Replicon: plasmid unnamed1
• Accession: NZ_CP048695
• Organism: Vibrio coralliilyticus OCN008

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: G3U99_RS26030
• Protein ID: WP_021458752.1
• Coordinates: 198866..199165 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A347UQT2
• Locus tag: G3U99_RS26035
• Protein ID: WP_005442033.1
• Coordinates: 199173..199415 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G3U99_RS26000	195268..196392	-	1125	WP_021458478.1	cyclopropane fatty acyl phospholipid synthase	-
G3U99_RS26005	196632..196991	+	360	WP_021458479.1	hypothetical protein	-
G3U99_RS26010	197227..197541	-	315	WP_021458480.1	hypothetical protein	-
G3U99_RS26015	198011..198397	+	387	WP_207623575.1	ester cyclase	-
G3U99_RS26020	198410..198703	+	294	Protein_187	hypothetical protein	-
G3U99_RS26025	198700..198810	+	111	WP_085058213.1	DUF3265 domain-containing protein	-
G3U99_RS26030	198866..199165	-	300	WP_021458752.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G3U99_RS26035	199173..199415	-	243	WP_005442033.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
G3U99_RS26040	199691..199927	+	237	WP_021458677.1	hypothetical protein	-
G3U99_RS26045	200086..200376	-	291	WP_006958738.1	type II toxin-antitoxin system RelE/ParE family toxin	-
G3U99_RS26050	200366..200614	-	249	WP_005377003.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
G3U99_RS26055	200946..201536	+	591	WP_021458678.1	Crp/Fnr family transcriptional regulator	-
G3U99_RS26060	201598..202044	+	447	WP_019274826.1	isoprenylcysteine carboxylmethyltransferase family protein	-
G3U99_RS26065	202166..202921	+	756	WP_021458679.1	isocitrate lyase/phosphoenolpyruvate mutase family protein	-
G3U99_RS26070	203081..203518	+	438	WP_085058204.1	GNAT family N-acetyltransferase	-
G3U99_RS26075	203661..204212	+	552	WP_021458681.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..244689	244689

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11424.08 Da
• Isoelectric Point: 9.3232

>T149897 WP_021458752.1 NZ_CP048695:c199165-198866 [Vibrio coralliilyticus OCN008]
MQKNKYKLSNLALSHLHKIKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDG
FILVVAVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T149897 NZ_CP064330:1392241-1392507 [Xylella fastidiosa subsp. fastidiosa]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAGCTCGACAAGCACATGGCGCGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAACCCACGCAGCAGTGGTAAAGCATTAACCGGACCACTTGGCGGCT
TTTGGCGTTATCGTGTTGGTGATTTCCGGGTCGTCTGCGCCATTCAAGATAGCGTTTTGCGCGTCCTTGTAGTGCGTGTT
GGTCACCGGGGTGAGATTTACCGATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9047.26 Da
• Isoelectric Point: 5.6926

>AT149897 WP_005442033.1 NZ_CP048695:c199415-199173 [Vibrio coralliilyticus OCN008]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL

Nucleotide

• Length: 243 bp

>AT149897 NZ_CP064330:1392030-1392257 [Xylella fastidiosa subsp. fastidiosa]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTGAACTCTCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTACGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTGTTGGAACGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGATGTGAGGAAAACGCTTGGCCTGGACGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A347UQT2