Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3907830..3908631 Replicon chromosome
Accession NZ_CP048692
Organism Proteus mirabilis strain HNS2p

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag G3T55_RS18060 Protein ID WP_001094437.1
Coordinates 3907830..3908207 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag G3T55_RS18065 Protein ID WP_001390338.1
Coordinates 3908254..3908631 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3T55_RS18025 (G3T55_18055) 3903023..3903706 - 684 WP_004246670.1 hypothetical protein -
G3T55_RS18030 (G3T55_18060) 3903796..3904419 - 624 WP_004246669.1 common pilus major fimbrillin subunit EcpA -
G3T55_RS18035 (G3T55_18065) 3904559..3904879 - 321 WP_004246668.1 helix-turn-helix transcriptional regulator -
G3T55_RS18040 (G3T55_18070) 3905700..3905885 - 186 Protein_3517 virulence RhuM family protein -
G3T55_RS18045 (G3T55_18075) 3906198..3907043 - 846 WP_001274561.1 DUF4942 domain-containing protein -
G3T55_RS18050 (G3T55_18080) 3907128..3907325 - 198 WP_000772032.1 DUF957 domain-containing protein -
G3T55_RS18055 (G3T55_18085) 3907345..3907833 - 489 WP_000761716.1 DUF5983 family protein -
G3T55_RS18060 (G3T55_18090) 3907830..3908207 - 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
G3T55_RS18065 (G3T55_18095) 3908254..3908631 - 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
G3T55_RS18070 (G3T55_18100) 3908794..3909015 - 222 WP_000692345.1 DUF987 domain-containing protein -
G3T55_RS18075 (G3T55_18105) 3909078..3909554 - 477 WP_001535682.1 RadC family protein -
G3T55_RS18080 (G3T55_18110) 3909570..3910043 - 474 WP_000855064.1 antirestriction protein -
G3T55_RS18085 (G3T55_18115) 3910385..3911203 - 819 WP_001535681.1 DUF932 domain-containing protein -
G3T55_RS18090 (G3T55_18120) 3911321..3911516 - 196 Protein_3527 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catA1 / dfrA12 / aadA2 / qacE / sul1 / qnrA1 / floR / tet(G) / rmtB / blaTEM-1B / erm(42) - 3907128..4006133 99005


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T149892 WP_001094437.1 NZ_CP048692:c3908207-3907830 [Proteus mirabilis]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T149892 NZ_CP064330:457996-458298 [Xylella fastidiosa subsp. fastidiosa]
ATGGAGAAAGGCACATCTCACTATAAGCTACCAGTCGTCAAAGCCTTGGTGAAAGCTGGCAAGGTCAGGGCTACAGCGAC
CGCCTACCAAGGAGCACGTGAGCTCGGCATCAAAGATTTAACTGGAATGTGCACCGTTGTCTTGGCGCTCACGTCTGCCG
ACTTCTACAAGAGCATGACGACCTACGCGGATCACACAGTATTCCAGGATGTGTACCACGCCAAGACGGCAAGCGGTGAT
GAGGTGTACCTGAAGTTAACTGTCATTGATGACGTGTTGATTGTTTCCTTCAAGGAGTTATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT149892 WP_001390338.1 NZ_CP048692:c3908631-3908254 [Proteus mirabilis]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT149892 NZ_CP064330:458301-458702 [Xylella fastidiosa subsp. fastidiosa]
ATGAGATGTCCATGCTGCGGCGCGGCAGAACTGATCCACGACACGCGCGACATGCTTTACACCTACAAGAGCGAAACTAC
TAGTATCCCAACGGTGACCGGCGACTTCTGCCCGGCTTGTGGCGAAGTCGTCTTGGACCGTGAACATGGTGATCGTTACA
GCGAATTGGTCGGCTTGTTCCAACGTCAGGTGAATTCGGCCTACGTCGATCCTGGTTACATTACCAAGGTACGCCGGAAG
CTTGATCTCGACCAGCGGCAAGCTGCCGAACTGTTCGGTGGTGGTGTTAATGCTTTCTCACGTTACGAGAACGGTAAAAC
CAAGCCGCCGCTGTCTTTGGTTAAGTTATTCAAGCTTCTGGATCGCCACCCCGATTTGCTCAACGAAGTGAAGAGTTCCT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References