Detailed information of TA system TA149891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3736341..3737040
• Replicon: chromosome
• Accession: NZ_CP048692
• Organism: Proteus mirabilis strain HNS2p

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: G3T55_RS17280
• Protein ID: WP_004249093.1
• Coordinates: 3736341..3736727 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: G3T55_RS17285
• Protein ID: WP_004246828.1
• Coordinates: 3736720..3737040 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G3T55_RS17265 (G3T55_17295)	3732360..3732941	-	582	WP_004246833.1	DNA-3-methyladenine glycosylase I	-
G3T55_RS17270 (G3T55_17300)	3733192..3734097	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
G3T55_RS17275 (G3T55_17305)	3734107..3736179	+	2073	WP_041701373.1	glycine--tRNA ligase subunit beta	-
G3T55_RS17280 (G3T55_17310)	3736341..3736727	+	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G3T55_RS17285 (G3T55_17315)	3736720..3737040	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
G3T55_RS17290 (G3T55_17320)	3737089..3737523	-	435	WP_004246827.1	hypothetical protein	-
G3T55_RS17295 (G3T55_17325)	3737516..3738400	-	885	WP_110706881.1	endonuclease/exonuclease/phosphatase family protein	-
G3T55_RS17300 (G3T55_17330)	3738617..3739903	-	1287	WP_049256516.1	DUF3748 domain-containing protein	-
G3T55_RS17305 (G3T55_17335)	3740040..3740657	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
G3T55_RS17310 (G3T55_17340)	3740959..3741582	+	624	WP_004246821.1	guanylate kinase	-
G3T55_RS17315 (G3T55_17345)	3741637..3741912	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T149891 WP_004249093.1 NZ_CP048692:3736341-3736727 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T149891 NZ_CP064330:457996-458298 [Xylella fastidiosa subsp. fastidiosa]
ATGGAGAAAGGCACATCTCACTATAAGCTACCAGTCGTCAAAGCCTTGGTGAAAGCTGGCAAGGTCAGGGCTACAGCGAC
CGCCTACCAAGGAGCACGTGAGCTCGGCATCAAAGATTTAACTGGAATGTGCACCGTTGTCTTGGCGCTCACGTCTGCCG
ACTTCTACAAGAGCATGACGACCTACGCGGATCACACAGTATTCCAGGATGTGTACCACGCCAAGACGGCAAGCGGTGAT
GAGGTGTACCTGAAGTTAACTGTCATTGATGACGTGTTGATTGTTTCCTTCAAGGAGTTATGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT149891 WP_004246828.1 NZ_CP048692:3736720-3737040 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT149891 NZ_CP064330:457633-457908 [Xylella fastidiosa subsp. fastidiosa]
ATGAAACGTATGCACAATCCCGCACATCCAGGTGAAGTGTTGCGTGAGTATCTTGGTGAGCTCACTGTGACCAATGCGGC
TGCAAAGCTAGGCGTCAGCCGTGTGGCTTTGTCGCGTATTCTCAATGGTACCAATGGCATCTCTGCCGATATGGCCCTTC
GCCTGGAAGATGCGCTTGGCACCAGTGCAGAGATGTGGGCAGCCATGCAGTTCAAGTATGACCTGTGGGTTGCTAGTCAG
CAGCCACGCCCGAAGATCACGCGCCTTCATGTTTAG

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97