Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 3406550..3407020 Replicon chromosome
Accession NZ_CP048692
Organism Proteus mirabilis strain HNS2p

Toxin (Protein)


Gene name VapD Uniprot ID A0A8E4FU70
Locus tag G3T55_RS15785 Protein ID WP_060555119.1
Coordinates 3406742..3407020 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A8E4FTC4
Locus tag G3T55_RS15780 Protein ID WP_060555126.1
Coordinates 3406550..3406738 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3T55_RS15745 (G3T55_15770) 3401858..3403057 - 1200 WP_049218680.1 lipoprotein-releasing ABC transporter permease subunit LolC -
G3T55_RS15750 (G3T55_15775) 3403359..3403760 + 402 WP_049218678.1 g-type lysoyme inhibitor PliG -
G3T55_RS15755 (G3T55_15780) 3404177..3404578 - 402 WP_060555124.1 phage holin family protein -
G3T55_RS15760 (G3T55_15785) 3404660..3405013 - 354 WP_060555123.1 hypothetical protein -
G3T55_RS15765 (G3T55_15790) 3405085..3405333 - 249 WP_060555122.1 DUF883 family protein -
G3T55_RS15770 (G3T55_15795) 3405783..3406130 + 348 WP_060555121.1 type II toxin-antitoxin system RelE/ParE family toxin -
G3T55_RS15775 (G3T55_15800) 3406130..3406429 + 300 WP_060555120.1 XRE family transcriptional regulator -
G3T55_RS19710 3406448..3406552 + 105 Protein_3069 transcriptional regulator -
G3T55_RS15780 (G3T55_15805) 3406550..3406738 + 189 WP_060555126.1 DUF5397 family protein Antitoxin
G3T55_RS15785 (G3T55_15810) 3406742..3407020 + 279 WP_060555119.1 virulence factor Toxin
G3T55_RS15790 (G3T55_15815) 3407487..3408977 + 1491 WP_060555118.1 YadA-like family protein -
G3T55_RS15795 (G3T55_15820) 3409164..3409238 - 75 Protein_3073 IS200/IS605 family transposase -
G3T55_RS15800 (G3T55_15825) 3409232..3409339 - 108 Protein_3074 transposase -
G3T55_RS15805 (G3T55_15830) 3409389..3409595 - 207 WP_060555117.1 plasmid partition protein ParG -
G3T55_RS15810 (G3T55_15835) 3409592..3410215 - 624 WP_060555116.1 ParA family protein -
G3T55_RS15815 (G3T55_15840) 3410684..3411202 - 519 WP_060555115.1 ClbS/DfsB family four-helix bundle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(J) / blaCMY-2 - 3263596..3450396 186800


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(5-62)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10589.85 Da        Isoelectric Point: 6.4606

>T149890 WP_060555119.1 NZ_CP048692:3406742-3407020 [Proteus mirabilis]
MYAISFDLTVADTEKHHPKGVSQAYNDISSTLKRYGFERIQGSLYTNSDENMANLFQAMNALKALEWFPNSVRDIRAFRI
EQWSDFTSSMKG

Download         Length: 279 bp

>T149890 NZ_CP064330:457341-457622 [Xylella fastidiosa subsp. fastidiosa]
ATGATCAAAAGTTTCCGCCACAAAGGCATTCAACAATTCTTCCTCAAGGGATCAACCGCTGGTATCCAAACCAAACACGC
CGCCAAACTGCGTATCCAGCTCACCGCGTTGGAGAGTGCCAAGCGCCCCGAAGATATGAATGCTCCAGGCTGGAAACTGC
ACCCACTAAAAGGCGCTGACTTAAAAGGTCATTGGTCCATCTGGGTGAATGGCAACTATCGCCTCACGTTTGCTTTTGAA
GGCGAAGACGCAATCTTGGTCGACTATCAGGATTATCACTAG

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6787.78 Da        Isoelectric Point: 3.9020

>AT149890 WP_060555126.1 NZ_CP048692:3406550-3406738 [Proteus mirabilis]
MNTVQIPTGSIKTFGLFGIPYEVGEPAQELPDGDILVNIILVQTGEKELYKLSKLLQDPDAE

Download         Length: 189 bp

>AT149890 NZ_CP064330:457633-457908 [Xylella fastidiosa subsp. fastidiosa]
ATGAAACGTATGCACAATCCCGCACATCCAGGTGAAGTGTTGCGTGAGTATCTTGGTGAGCTCACTGTGACCAATGCGGC
TGCAAAGCTAGGCGTCAGCCGTGTGGCTTTGTCGCGTATTCTCAATGGTACCAATGGCATCTCTGCCGATATGGCCCTTC
GCCTGGAAGATGCGCTTGGCACCAGTGCAGAGATGTGGGCAGCCATGCAGTTCAAGTATGACCTGTGGGTTGCTAGTCAG
CAGCCACGCCCGAAGATCACGCGCCTTCATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References