149885

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 5160910..5161885 Replicon chromosome
Accession NZ_CP048687
Organism Bacillus paranthracis strain MN1F

Toxin (Protein)


Gene name spoIISA Uniprot ID B7HS47
Locus tag G3T58_RS26220 Protein ID WP_002027714.1
Coordinates 5161148..5161885 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag G3T58_RS26215 Protein ID WP_000588712.1
Coordinates 5160910..5161035 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3T58_RS26190 5156291..5157118 - 828 WP_001060779.1 hypothetical protein -
G3T58_RS26195 5157108..5157641 - 534 WP_000438318.1 sigma-70 family RNA polymerase sigma factor -
G3T58_RS26200 5157863..5158456 - 594 WP_000265892.1 SGNH/GDSL hydrolase family protein -
G3T58_RS26205 5158599..5158970 + 372 WP_000670600.1 DUF5065 family protein -
G3T58_RS26210 5159047..5160515 - 1469 Protein_5160 beta-Ala-His dipeptidase -
G3T58_RS26215 5160910..5161035 - 126 WP_000588712.1 hypothetical protein Antitoxin
G3T58_RS26220 5161148..5161885 - 738 WP_002027714.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
G3T58_RS26225 5162074..5162811 - 738 WP_000594123.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
G3T58_RS26230 5162979..5163461 - 483 WP_000191904.1 MarR family winged helix-turn-helix transcriptional regulator -
G3T58_RS26235 5163568..5165253 + 1686 WP_002027713.1 alpha-keto acid decarboxylase family protein -
G3T58_RS29310 5165375..5165467 - 93 Protein_5166 methyltransferase -
G3T58_RS26240 5165573..5165980 - 408 WP_000072484.1 VOC family protein -
G3T58_RS26245 5166100..5166810 - 711 WP_000787481.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28415.15 Da        Isoelectric Point: 8.2672

>T149885 WP_002027714.1 NZ_CP048687:c5161885-5161148 [Bacillus paranthracis]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTSIIQNVNPVVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T149885 NZ_CP064328:1388437-1388742 [Xylella fastidiosa subsp. fastidiosa]
ATGAATAATGAGACTTTTAGTCGATACGACACCGCTGACTATCTCAAAACCGAAGAAGATATTGCGGCTTATATGGAAGC
CGTCATGGAAGAAGGTGGTAGGGATAATCCTGCTTTTATTGCACGGGCACTTGGTGCTGTCGCTCGTGCTCGTAATTTAA
GTCAGCTTGCTCGTGACGTTGGCATGTCCAGGCAAGGACTAGACAAGGCACTCTCTAACGACGGCAACCCAAGCTTCTCA
ACCATCTTAAAAGTGGCTAAAGCGCTTGGTTTACGGATGTCATTCACACCTTCCTCTATGAGTTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT149885 WP_000588712.1 NZ_CP048687:c5161035-5160910 [Bacillus paranthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT149885 NZ_CP064328:1388137-1388433 [Xylella fastidiosa subsp. fastidiosa]
ATGGTCGAACTCATCAAAACCAGCACTTTTGATGCTTGGATAAACAGCTTACGTGACCGCAAAGCAGCCGCCAGAATTCA
AGCGCGTCTTGATCGGCTCGCACTTGGCAATCCCGGCGACGTGAAGCCTGTGGGTGCTGGCATCTCAGAAATGAGGATCG
ACCATGGGCCCGGATATCGGATCTATTTTATGAAGCATGGTGCAGTACTGATTCTCTTACTTTGCGGTGGCGATAAATCG
TCACAAGTACGAGATATAGAGCAGGCTAAGGCACTGGCTGCACTGTGGAAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M9H7T3

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References