Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 5160910..5161885 Replicon chromosome
Accession NZ_CP048687
Organism Bacillus paranthracis strain MN1F

Toxin (Protein)


Gene name spoIISA Uniprot ID B7HS47
Locus tag G3T58_RS26220 Protein ID WP_002027714.1
Coordinates 5161148..5161885 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag G3T58_RS26215 Protein ID WP_000588712.1
Coordinates 5160910..5161035 (-) Length 42 a.a.

Genomic Context

G3T58_RS26205G3T58_RS26235G3T58_RS26190G3T58_RS26195G3T58_RS26200G3T58_RS26210G3T58_RS26215G3T58_RS26220G3T58_RS26225G3T58_RS26230G3T58_RS29310G3T58_RS26240G3T58_RS26245
Location: 5158599..5158970 (372 bp)
Type: Others
Protein ID: WP_000670600.1
Location: 5163568..5165253 (1686 bp)
Type: Others
Protein ID: WP_002027713.1
Location: 5156291..5157118 (828 bp)
Type: Others
Protein ID: WP_001060779.1
Location: 5157108..5157641 (534 bp)
Type: Others
Protein ID: WP_000438318.1
Location: 5157863..5158456 (594 bp)
Type: Others
Protein ID: WP_000265892.1
Location: 5159047..5160515 (1469 bp)
Type: Others
Protein ID: Protein_5160
Location: 5160910..5161035 (126 bp)
Type: Antitoxin
Protein ID: WP_000588712.1
Location: 5161148..5161885 (738 bp)
Type: Toxin
Protein ID: WP_002027714.1
Location: 5162074..5162811 (738 bp)
Type: Others
Protein ID: WP_000594123.1
Location: 5162979..5163461 (483 bp)
Type: Others
Protein ID: WP_000191904.1
Location: 5165375..5165467 (93 bp)
Type: Others
Protein ID: Protein_5166
Location: 5165573..5165980 (408 bp)
Type: Others
Protein ID: WP_000072484.1
Location: 5166100..5166810 (711 bp)
Type: Others
Protein ID: WP_000787481.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G3T58_RS261905156291..5157118-828WP_001060779.1hypothetical protein-
G3T58_RS261955157108..5157641-534WP_000438318.1sigma-70 family RNA polymerase sigma factor-
G3T58_RS262005157863..5158456-594WP_000265892.1SGNH/GDSL hydrolase family protein-
G3T58_RS262055158599..5158970+372WP_000670600.1DUF5065 family protein-
G3T58_RS262105159047..5160515-1469Protein_5160beta-Ala-His dipeptidase-
G3T58_RS262155160910..5161035-126WP_000588712.1hypothetical proteinAntitoxin
G3T58_RS262205161148..5161885-738WP_002027714.1type II toxin-antitoxin system SpoIISA family toxinToxin
G3T58_RS262255162074..5162811-738WP_000594123.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
G3T58_RS262305162979..5163461-483WP_000191904.1MarR family winged helix-turn-helix transcriptional regulator-
G3T58_RS262355163568..5165253+1686WP_002027713.1alpha-keto acid decarboxylase family protein-
G3T58_RS293105165375..5165467-93Protein_5166methyltransferase-
G3T58_RS262405165573..5165980-408WP_000072484.1VOC family protein-
G3T58_RS262455166100..5166810-711WP_000787481.1class I SAM-dependent methyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28415.15 Da        Isoelectric Point: 8.2672

>T149885 WP_002027714.1 NZ_CP048687:c5161885-5161148 [Bacillus paranthracis]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTSIIQNVNPVVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T149885 NZ_CP064328:1388437-1388742 [Xylella fastidiosa subsp. fastidiosa]
ATGAATAATGAGACTTTTAGTCGATACGACACCGCTGACTATCTCAAAACCGAAGAAGATATTGCGGCTTATATGGAAGC
CGTCATGGAAGAAGGTGGTAGGGATAATCCTGCTTTTATTGCACGGGCACTTGGTGCTGTCGCTCGTGCTCGTAATTTAA
GTCAGCTTGCTCGTGACGTTGGCATGTCCAGGCAAGGACTAGACAAGGCACTCTCTAACGACGGCAACCCAAGCTTCTCA
ACCATCTTAAAAGTGGCTAAAGCGCTTGGTTTACGGATGTCATTCACACCTTCCTCTATGAGTTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT149885 WP_000588712.1 NZ_CP048687:c5161035-5160910 [Bacillus paranthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT149885 NZ_CP064328:1388137-1388433 [Xylella fastidiosa subsp. fastidiosa]
ATGGTCGAACTCATCAAAACCAGCACTTTTGATGCTTGGATAAACAGCTTACGTGACCGCAAAGCAGCCGCCAGAATTCA
AGCGCGTCTTGATCGGCTCGCACTTGGCAATCCCGGCGACGTGAAGCCTGTGGGTGCTGGCATCTCAGAAATGAGGATCG
ACCATGGGCCCGGATATCGGATCTATTTTATGAAGCATGGTGCAGTACTGATTCTCTTACTTTGCGGTGGCGATAAATCG
TCACAAGTACGAGATATAGAGCAGGCTAAGGCACTGGCTGCACTGTGGAAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5M9H7T3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366GQT1

References