149884

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 1614985..1615627 Replicon chromosome
Accession NZ_CP048687
Organism Bacillus paranthracis strain MN1F

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag G3T58_RS08045 Protein ID WP_000635963.1
Coordinates 1614985..1615335 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag G3T58_RS08050 Protein ID WP_000004570.1
Coordinates 1615340..1615627 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3T58_RS08030 1611921..1612379 - 459 WP_000344246.1 SprT family protein -
G3T58_RS08035 1612575..1612691 + 117 WP_001143642.1 cortex morphogenetic protein CmpA -
G3T58_RS08040 1612749..1614917 - 2169 WP_000450602.1 RNA-binding transcriptional accessory protein -
G3T58_RS08045 1614985..1615335 - 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
G3T58_RS08050 1615340..1615627 - 288 WP_000004570.1 antitoxin EndoAI Antitoxin
G3T58_RS08055 1615927..1617096 - 1170 WP_000390601.1 alanine racemase -
G3T58_RS08060 1617215..1618165 - 951 WP_025991724.1 outer membrane lipoprotein carrier protein LolA -
G3T58_RS08065 1618322..1618681 - 360 WP_000635037.1 holo-ACP synthase -
G3T58_RS08070 1618774..1619346 + 573 WP_000906919.1 rhomboid family intramembrane serine protease -
G3T58_RS08075 1619339..1620301 - 963 WP_000961151.1 UV DNA damage repair endonuclease UvsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T149884 WP_000635963.1 NZ_CP048687:c1615335-1614985 [Bacillus paranthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T149884 NZ_CP064328:1388137-1388433 [Xylella fastidiosa subsp. fastidiosa]
ATGGTCGAACTCATCAAAACCAGCACTTTTGATGCTTGGATAAACAGCTTACGTGACCGCAAAGCAGCCGCCAGAATTCA
AGCGCGTCTTGATCGGCTCGCACTTGGCAATCCCGGCGACGTGAAGCCTGTGGGTGCTGGCATCTCAGAAATGAGGATCG
ACCATGGGCCCGGATATCGGATCTATTTTATGAAGCATGGTGCAGTACTGATTCTCTTACTTTGCGGTGGCGATAAATCG
TCACAAGTACGAGATATAGAGCAGGCTAAGGCACTGGCTGCACTGTGGAAGGATTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT149884 WP_000004570.1 NZ_CP048687:c1615627-1615340 [Bacillus paranthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT149884 NZ_CP064328:1388437-1388742 [Xylella fastidiosa subsp. fastidiosa]
ATGAATAATGAGACTTTTAGTCGATACGACACCGCTGACTATCTCAAAACCGAAGAAGATATTGCGGCTTATATGGAAGC
CGTCATGGAAGAAGGTGGTAGGGATAATCCTGCTTTTATTGCACGGGCACTTGGTGCTGTCGCTCGTGCTCGTAATTTAA
GTCAGCTTGCTCGTGACGTTGGCATGTCCAGGCAAGGACTAGACAAGGCACTCTCTAACGACGGCAACCCAAGCTTCTCA
ACCATCTTAAAAGTGGCTAAAGCGCTTGGTTTACGGATGTCATTCACACCTTCCTCTATGAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References