Detailed information of TA system TA149859

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2189738..2190362
• Replicon: chromosome
• Accession: NZ_CP048654
• Organism: Acinetobacter indicus strain C15_T

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: N9KY14
• Locus tag: G0027_RS10625
• Protein ID: WP_005180237.1
• Coordinates: 2189970..2190362 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: G0027_RS10620
• Protein ID: WP_171065118.1
• Coordinates: 2189738..2189983 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0027_RS10600	2185200..2186207	+	1008	WP_005180245.1	DNA-directed RNA polymerase subunit alpha	-
G0027_RS10605	2186227..2186592	+	366	WP_004754212.1	50S ribosomal protein L17	-
G0027_RS10610	2186792..2188282	+	1491	WP_005180241.1	NAD(P)/FAD-dependent oxidoreductase	-
G0027_RS10615	2188370..2189542	-	1173	WP_075167404.1	acyl-CoA dehydrogenase family protein	-
G0027_RS10620	2189738..2189983	+	246	WP_171065118.1	succinate dehydrogenase assembly factor 2	Antitoxin
G0027_RS10625	2189970..2190362	+	393	WP_005180237.1	hypothetical protein	Toxin
G0027_RS10630	2190510..2190689	-	180	WP_127801044.1	hypothetical protein	-
G0027_RS10635	2190879..2191952	+	1074	WP_016658537.1	hypothetical protein	-
G0027_RS10640	2192008..2192580	+	573	WP_127799341.1	rhombosortase	-
G0027_RS10645	2192761..2195037	+	2277	WP_127799343.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14930.64 Da
• Isoelectric Point: 10.4540

>T149859 WP_005180237.1 NZ_CP048654:2189970-2190362 [Acinetobacter indicus]
MSTAKRDFQLKPSRLALLFQLSLLILFSVLSFQLLHPLLWLLGLLLAAVSYYGFQRRSQLTALAHLDGAEWSLQFNSGSK
IQRGLLEHILDHQLYLVLYFHHAPVKSAVIWRDQVSFAEWKALKTLAKTI

Nucleotide

• Length: 393 bp

>T149859 NZ_CP064316:1325372-1325674 [Lacticaseibacillus paracasei subsp. tolerans]
ATGTATAGTCTGGTTCCGACGCCTACATTTAAGCGCGATCTAAAACGACTCTCCAAGAAGCATTGGCCGATGGACGAACT
AAAGACGGCTGTTAATCTCCTAGCCGCTGGTACAAATGCTGAACTATTAAGCAAAAAGTATGCAGATCATGCCTTGTCCT
CAAGCAGCGAGTGGAAAGGATATCGTGAACTATATGTTGACGGCCCTCGTGGCGACTGGTTGCTAATCTATAAAATTGAG
CAGCAAGATCTTATTTTAACCCTAGTTAGAACCGGATCTCATCATAACCTTCTGGTTAAATAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9758.15 Da
• Isoelectric Point: 4.9108

>AT149859 WP_171065118.1 NZ_CP048654:2189738-2189983 [Acinetobacter indicus]
ISLEERKVIYRARRGLKEIDVYFDPYVKNYYLTADPEEKATFAALVEQEDPDLLDWFMEVSEPPRPEMRELIRKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT149859 NZ_CP064316:1325110-1325379 [Lacticaseibacillus paracasei subsp. tolerans]
ATGGCAGCCACAAAGAAGGAAACTCGCTTGAATATTCGTGTTGATCCTGAATTAAAAAGTGCTGCTCAAATCGTAGCAAA
TGATATGGGCATCGACTTGACCGCAGCTGTTACGATGTTCATGACGAAAATGGTGAAAGATCACGCCCTCCCGTTTACCC
CAACAAGTCTACCAGTTGAAACCTTACAGGCGCTGAAAGAAGCAAAGCACCCAGAGCTGCTCAAAAAATACAGCACGCCT
GATGACATGTGGAGAGACTTGAATGTATAG

Structures

Toxin

• AlphaFold DB: N9KY14