Detailed information of TA system TA149858

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2004201..2004729
• Replicon: chromosome
• Accession: NZ_CP048654
• Organism: Acinetobacter indicus strain C15_T

Toxin (Protein)

• Gene name: relE
• Uniprot ID: N9N871
• Locus tag: G0027_RS09615
• Protein ID: WP_000221358.1
• Coordinates: 2004436..2004729 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G0027_RS09610
• Protein ID: WP_104988060.1
• Coordinates: 2004201..2004446 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0027_RS09590	1999413..2001278	+	1866	WP_104988058.1	copper resistance system multicopper oxidase	-
G0027_RS09595	2001265..2001603	+	339	WP_104988059.1	hypothetical protein	-
G0027_RS09600	2001590..2002534	+	945	WP_004668309.1	copper resistance protein B	-
G0027_RS09605	2002766..2004091	+	1326	WP_163169897.1	ISNCY family transposase	-
G0027_RS09610	2004201..2004446	+	246	WP_104988060.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
G0027_RS09615	2004436..2004729	+	294	WP_000221358.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G0027_RS09620	2004858..2005187	-	330	WP_004641881.1	four-helix bundle copper-binding protein	-
G0027_RS09625	2005435..2006525	+	1091	Protein_1864	IS3 family transposase	-
G0027_RS09630	2007241..2007804	+	564	WP_016658414.1	alkyl hydroperoxide reductase subunit C	-
G0027_RS09635	2008005..2008880	+	876	WP_180192268.1	pirin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1975357..2006525	31168
	-	inside	IScluster/Tn	-	-	2002754..2006525	3771

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11292.52 Da
• Isoelectric Point: 10.4753

>T149858 WP_000221358.1 NZ_CP048654:2004436-2004729 [Acinetobacter indicus]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Nucleotide

• Length: 294 bp

>T149858 NZ_CP064314:c2663510-2663127 [Lacticaseibacillus paracasei subsp. tolerans]
ATGGATGTGTCCGTAAAACGCGGCGATGTTTTTTTCGCCGATCTGTCTCCGGTTGTCGGCTCCGAACAAGGCGGCAACCG
GCCAGTACTTATTATTCAAAACAACGTTGGCAACCATTACAGTCCCACAGTGATTGTGGCAGCCATTACCTCCAAGATTC
AAAAACCCAAGATGCCGACGCATGTCGGGTTACGGGCCAAGCAAGATGGCGTTGAACGCAACTCAGTCATTTTACTTGAG
CAAATTCGCACGATTGACAAGCAACGGCTACAAGCCCGCGTGACAGCTCTGTCAAGCACCAAAATGGCAGCAGTCGACCG
CGCGTTGGCGATTTCAGTGGGCTTGGTTAGTTTGCCCAAGCCCAAAACATATAATAAGAATTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9279.66 Da
• Isoelectric Point: 4.3142

>AT149858 WP_104988060.1 NZ_CP048654:2004201-2004446 [Acinetobacter indicus]
MATVNFRIDEALKEKSYSILKEQGITPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Nucleotide

• Length: 246 bp

>AT149858 NZ_CP064314:c2663778-2663530 [Lacticaseibacillus paracasei subsp. tolerans]
ATGAAAAAGCAAACGTCAGTAGCGGTAACGTTTGATGATGCCATTAAGGCGCGGTTGGATGCCTATTGTGAATTGAATGA
CATTGACGCTCAGGCTGTGATTACGGAGGCGGTGGCGACATTTTTGAAGTCACAGGCTCCCGAAATCAACCAATTGATTT
CTGGCTATGTAGCAATGGGCCAGATCAATACAGAGATCAGTCATGCTTTCTCTGCCTGCGAGAGCGAGGCATACGCCCAT
ATTCGATGA

Structures

Toxin

• AlphaFold DB: A0A6A1RKP4