Detailed information of TA system TA149852

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4038959..4039616
• Replicon: chromosome
• Accession: NZ_CP048650
• Organism: Enterobacter roggenkampii strain Ecl_20_981

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: W7P4L3
• Locus tag: G3T53_RS19325
• Protein ID: WP_023326024.1
• Coordinates: 4038959..4039369 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W7NX65
• Locus tag: G3T53_RS19330
• Protein ID: WP_006178375.1
• Coordinates: 4039350..4039616 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G3T53_RS19305	4034952..4036685	-	1734	WP_044597689.1	single-stranded-DNA-specific exonuclease RecJ	-
G3T53_RS19310	4036691..4037404	-	714	WP_044597688.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
G3T53_RS19315	4037433..4038329	-	897	WP_044597687.1	site-specific tyrosine recombinase XerD	-
G3T53_RS19320	4038431..4038952	+	522	WP_044597686.1	flavodoxin FldB	-
G3T53_RS19325	4038959..4039369	-	411	WP_023326024.1	protein YgfX	Toxin
G3T53_RS19330	4039350..4039616	-	267	WP_006178375.1	FAD assembly factor SdhE	Antitoxin
G3T53_RS19335	4039911..4040891	+	981	WP_044597685.1	tRNA-modifying protein YgfZ	-
G3T53_RS19340	4040976..4041635	-	660	WP_021242052.1	hemolysin III family protein	-
G3T53_RS19345	4041901..4042632	+	732	WP_021242053.1	MurR/RpiR family transcriptional regulator	-
G3T53_RS19350	4042749..4044182	+	1434	WP_044597684.1	6-phospho-beta-glucosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16063.06 Da
• Isoelectric Point: 10.9468

>T149852 WP_023326024.1 NZ_CP048650:c4039369-4038959 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Nucleotide

• Length: 411 bp

>T149852 NZ_CP064304:2401494-2401877 [Lacticaseibacillus paracasei subsp. tolerans]
ATGGATGTGTCCGTAAAACGCGGCGATGTTTTTTTCGCCGATCTGTCTCCGGTTGTCGGCTCCGAACAAGGCGGCAACCG
GCCAGTACTTATTATTCAAAACAACGTTGGCAACCATTACAGTCCCACAGTGATTGTGGCAGCCATTACCTCCAAGATTC
AAAAACCCAAGATGCCGACGCATGTCGGGTTACGGGCCAAGCAAGATGGCGTTGAACGCAACTCGGTCATTTTACTTGAG
CAAATTCGCACGATTGACAAGCAACGGCTACAAGCCCGCGTGACAGCTCTGTCAAGCACCAAAATGGCAGCAGTCGACCG
CGCGTTGGCGATTTCAGTGGGTCTGGTCAGTTTGCCCAAGCCCAAAACATATAATAAGAATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10569.05 Da
• Isoelectric Point: 5.1340

>AT149852 WP_006178375.1 NZ_CP048650:c4039616-4039350 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT149852 NZ_CP064304:2401226-2401474 [Lacticaseibacillus paracasei subsp. tolerans]
ATGAAAAAGCAAACGTCAGTAGCGGTAACGTTTGATGATGCCATTAAGGCGCGGTTGGATGCCTATTGTGAATTGAATGA
CATTGACGCTCAGGCTGTGATTACGGAGGCAGTGGCGACATTTTTGAAGTCACAGGCTCCCGAAATCAAACAATTGATTT
CTGGCTATGTAGCAATGGGCCAGATCAATACAGAGATCAGTCATGCTTTCTCTGCCTGCGAGAGCGAGGCATACGCCCAT
ATTCGATGA

Structures

Toxin

• AlphaFold DB: W7P4L3

Antitoxin

• AlphaFold DB: W7NX65