Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-Axe/YoeB-RelB
Location 861840..862365 Replicon chromosome
Accession NZ_CP048649
Organism Aminipila butyrica strain DSM 103574

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag Ami103574_RS04145 Protein ID WP_163065426.1
Coordinates 861840..862100 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID -
Locus tag Ami103574_RS04150 Protein ID WP_163065427.1
Coordinates 862093..862365 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Ami103574_RS04120 856844..857203 - 360 WP_163065421.1 helix-turn-helix transcriptional regulator -
Ami103574_RS04125 857265..858080 - 816 WP_163065422.1 hypothetical protein -
Ami103574_RS04130 858070..859674 - 1605 WP_163065423.1 hypothetical protein -
Ami103574_RS04135 859676..860035 - 360 WP_163065424.1 BlaI/MecI/CopY family transcriptional regulator -
Ami103574_RS04140 860653..861597 + 945 WP_163065425.1 DUF5105 domain-containing protein -
Ami103574_RS04145 861840..862100 - 261 WP_163065426.1 Txe/YoeB family addiction module toxin Toxin
Ami103574_RS04150 862093..862365 - 273 WP_163065427.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Ami103574_RS04155 862448..863605 - 1158 WP_163065428.1 site-specific integrase -
Ami103574_RS04160 863595..864131 - 537 WP_163065429.1 helix-turn-helix domain-containing protein -
Ami103574_RS04165 864298..864504 + 207 WP_163065430.1 helix-turn-helix transcriptional regulator -
Ami103574_RS04170 864506..864757 + 252 WP_163065431.1 hypothetical protein -
Ami103574_RS04175 864736..864939 + 204 WP_163065432.1 DNA-binding protein -
Ami103574_RS04180 864926..865345 + 420 WP_163065433.1 replication initiator protein A -
Ami103574_RS04185 865315..865716 + 402 WP_163065434.1 phage replisome organizer N-terminal domain-containing protein -
Ami103574_RS04190 865989..866273 + 285 WP_163065435.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 857265..940813 83548


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10279.71 Da        Isoelectric Point: 8.0353

>T149839 WP_163065426.1 NZ_CP048649:c862100-861840 [Aminipila butyrica]
MNKMFSKNAWEDYALWLQEDRKVLRRINDILKDIERNGHEGIGRPEPLKHALSGYWSRRITEKDRLVYKIADDTIYILGC
KGHYDD

Download         Length: 261 bp

>T149839 NZ_CP064260:16929-17078 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10551.99 Da        Isoelectric Point: 4.5332

>AT149839 WP_163065427.1 NZ_CP048649:c862365-862093 [Aminipila butyrica]
MLAVNYSTIRNNLKNYCDLVTENCETVIVTRKDEKNVVMISLDKYNNMLENLFIMSDKVNYERLLESKEQFDKHQGITKT
TEELEALANE

Download         Length: 273 bp

>AT149839 NZ_CP064260:c16884-16825 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References