Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1879042..1879873 Replicon chromosome
Accession NZ_CP048647
Organism Escherichia coli strain GW-AmxH19

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag G3273_RS08830 Protein ID WP_000854814.1
Coordinates 1879042..1879416 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A366YXM1
Locus tag G3273_RS08835 Protein ID WP_001518724.1
Coordinates 1879505..1879873 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3273_RS08790 1874438..1875604 + 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
G3273_RS08795 1875723..1876196 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
G3273_RS08800 1876394..1877452 + 1059 WP_001200894.1 FUSC family protein -
G3273_RS08805 1877624..1877953 + 330 WP_000450409.1 DUF496 family protein -
G3273_RS08810 1878054..1878236 - 183 WP_001016348.1 hypothetical protein -
G3273_RS08815 1878290..1878436 + 147 Protein_1721 transposase domain-containing protein -
G3273_RS08820 1878725..1878838 - 114 WP_001161660.1 DUF957 domain-containing protein -
G3273_RS08825 1878851..1879045 - 195 WP_000988601.1 hypothetical protein -
G3273_RS08830 1879042..1879416 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
G3273_RS08835 1879505..1879873 - 369 WP_001518724.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
G3273_RS08840 1879947..1880168 - 222 WP_000692323.1 DUF987 domain-containing protein -
G3273_RS08845 1880231..1880707 - 477 WP_001186773.1 RadC family protein -
G3273_RS08850 1880723..1881196 - 474 WP_000855075.1 antirestriction protein -
G3273_RS08855 1881459..1882280 - 822 WP_001234710.1 DUF945 domain-containing protein -
G3273_RS08860 1882501..1882911 - 411 WP_000846705.1 hypothetical protein -
G3273_RS08865 1882927..1883580 - 654 WP_001535423.1 hypothetical protein -
G3273_RS08870 1883637..1884370 + 734 Protein_1732 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T149818 WP_000854814.1 NZ_CP048647:c1879416-1879042 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T149818 NZ_CP064253:c102614-102465 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13441.24 Da        Isoelectric Point: 4.7594

>AT149818 WP_001518724.1 NZ_CP048647:c1879873-1879505 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLSSDADAYPLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLACEADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT149818 NZ_CP064253:102659-102718 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A366YXM1

References