149811

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2340834..2341363 Replicon chromosome
Accession NZ_CP048643
Organism Staphylococcus aureus strain SR153

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag GAU34_RS11675 Protein ID WP_001103933.1
Coordinates 2340834..2341151 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag GAU34_RS11680 Protein ID WP_001058487.1
Coordinates 2341154..2341363 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAU34_RS11645 2336049..2336390 - 342 WP_001190615.1 hypothetical protein -
GAU34_RS11650 2336840..2337481 - 642 WP_001019810.1 hypothetical protein -
GAU34_RS11655 2337478..2337762 - 285 WP_000998179.1 hypothetical protein -
GAU34_RS11660 2337764..2338126 - 363 WP_001039169.1 hypothetical protein -
GAU34_RS11665 2338412..2339881 - 1470 WP_001668899.1 virulence-associated E family protein -
GAU34_RS11670 2339898..2340767 - 870 WP_001002695.1 primase alpha helix C-terminal domain-containing protein -
GAU34_RS11675 2340834..2341151 - 318 WP_001103933.1 DUF1474 family protein Toxin
GAU34_RS11680 2341154..2341363 - 210 WP_001058487.1 hypothetical protein Antitoxin
GAU34_RS11685 2341356..2341502 - 147 WP_000784893.1 hypothetical protein -
GAU34_RS11690 2341499..2341726 - 228 WP_000164237.1 helix-turn-helix domain-containing protein -
GAU34_RS11695 2341762..2341968 - 207 WP_001060953.1 hypothetical protein -
GAU34_RS11700 2342126..2342773 + 648 WP_072474260.1 helix-turn-helix domain-containing protein -
GAU34_RS11705 2342779..2343885 + 1107 WP_000121223.1 site-specific integrase -
GAU34_RS11715 2344447..2344911 - 465 WP_001085183.1 SsrA-binding protein SmpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / sea / hlb / sell / sec / tsst-1 2279612..2347305 67693


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T149811 WP_001103933.1 NZ_CP048643:c2341151-2340834 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T149811 NZ_CP064252:4210010-4210228 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT149811 WP_001058487.1 NZ_CP048643:c2341363-2341154 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT149811 NZ_CP064252:4209609-4209983 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References