149804

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1138989..1139466 Replicon chromosome
Accession NZ_CP048643
Organism Staphylococcus aureus strain SR153

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag GAU34_RS05605 Protein ID WP_000052076.1
Coordinates 1138989..1139177 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag GAU34_RS05610 Protein ID WP_001059690.1
Coordinates 1139206..1139466 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAU34_RS05575 1134983..1135504 + 522 WP_000824482.1 hypothetical protein -
GAU34_RS05580 1135845..1136531 + 687 WP_000141557.1 thermonuclease family protein -
GAU34_RS05585 1136888..1137088 + 201 WP_001059082.1 cold-shock protein -
GAU34_RS05590 1137580..1137798 - 219 WP_000005886.1 hypothetical protein -
GAU34_RS05595 1137860..1138144 - 285 WP_001004399.1 hypothetical protein -
GAU34_RS05600 1138232..1138801 - 570 WP_001106654.1 hypothetical protein -
GAU34_RS05605 1138989..1139177 - 189 WP_000052076.1 hypothetical protein Toxin
GAU34_RS05610 1139206..1139466 - 261 WP_001059690.1 hypothetical protein Antitoxin
GAU34_RS05615 1139807..1140010 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
GAU34_RS05620 1140007..1140243 - 237 WP_000349581.1 hypothetical protein -
GAU34_RS05625 1140468..1141049 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
GAU34_RS05630 1141122..1141739 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
GAU34_RS05635 1141894..1142388 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
GAU34_RS05640 1142787..1143209 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
GAU34_RS05645 1143357..1144073 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T149804 WP_000052076.1 NZ_CP048643:c1139177-1138989 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T149804 NZ_CP064251:2792-3058 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT149804 WP_001059690.1 NZ_CP048643:c1139466-1139206 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT149804 NZ_CP064251:2584-2808 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References