Detailed information of TA system TA149803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1112464..1112942
• Replicon: chromosome
• Accession: NZ_CP048643
• Organism: Staphylococcus aureus strain SR153

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A0H3K0C1
• Locus tag: GAU34_RS05450
• Protein ID: WP_001078344.1
• Coordinates: 1112616..1112942 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: GAU34_RS05445
• Protein ID: WP_025175789.1
• Coordinates: 1112464..1112613 (+)
• Length: 50 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GAU34_RS05410	1107650..1107934	+	285	WP_000917289.1	co-chaperone GroES	-
GAU34_RS05415	1108010..1109626	+	1617	WP_000240642.1	chaperonin GroEL	-
GAU34_RS05420	1109695..1110867	-	1173	WP_000179343.1	site-specific integrase	-
GAU34_RS05425	1110881..1111555	-	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
GAU34_RS05430	1111728..1111946	+	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
GAU34_RS05435	1111951..1112268	+	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
GAU34_RS05440	1112265..1112411	+	147	WP_000784885.1	hypothetical protein	-
GAU34_RS05445	1112464..1112613	+	150	WP_025175789.1	hypothetical protein	Antitoxin
GAU34_RS05450	1112616..1112942	+	327	WP_001078344.1	DUF1474 family protein	Toxin
GAU34_RS05455	1113007..1113876	+	870	WP_001002689.1	primase alpha helix C-terminal domain-containing protein	-
GAU34_RS05460	1113890..1115598	+	1709	Protein_1071	DUF927 domain-containing protein	-
GAU34_RS05465	1115908..1116288	+	381	WP_000356942.1	hypothetical protein	-
GAU34_RS05470	1116285..1116926	+	642	WP_001047698.1	hypothetical protein	-
GAU34_RS05475	1117376..1117717	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	1104715..1128318	23603

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12968.26 Da
• Isoelectric Point: 4.3050

>T149803 WP_001078344.1 NZ_CP048643:1112616-1112942 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T149803 NZ_CP064250:c6346-6032 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin

Protein

• Length: 50 a.a.
• Molecular weight: 5822.52 Da
• Isoelectric Point: 4.4876

>AT149803 WP_025175789.1 NZ_CP048643:1112464-1112613 [Staphylococcus aureus]
VNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 150 bp

>AT149803 NZ_CP064250:c6612-6334 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3K0C1