Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1040627..1041141 Replicon chromosome
Accession NZ_CP048643
Organism Staphylococcus aureus strain SR153

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag GAU34_RS05090 Protein ID WP_000581792.1
Coordinates 1040932..1041141 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag GAU34_RS05085 Protein ID WP_000138932.1
Coordinates 1040627..1040920 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAU34_RS05050 1035790..1036431 + 642 WP_000483153.1 thiamine phosphate synthase -
GAU34_RS05055 1036517..1037389 + 873 WP_000725802.1 membrane protein insertase YidC -
GAU34_RS05075 1038302..1038949 - 648 WP_001187630.1 HD domain-containing protein -
GAU34_RS05080 1038977..1040461 - 1485 WP_000571549.1 cardiolipin synthase -
GAU34_RS05085 1040627..1040920 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
GAU34_RS05090 1040932..1041141 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
GAU34_RS05095 1041269..1041406 + 138 WP_000828354.1 hypothetical protein -
GAU34_RS05100 1041670..1042872 - 1203 WP_001109939.1 rod shape-determining protein RodA -
GAU34_RS05105 1043190..1044260 + 1071 WP_042109557.1 D-alanine--D-alanine ligase -
GAU34_RS05110 1044275..1045633 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T149801 WP_000581792.1 NZ_CP048643:1040932-1041141 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T149801 NZ_CP064248:39090-39248 [Klebsiella pneumoniae]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT149801 WP_000138932.1 NZ_CP048643:1040627-1040920 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT149801 NZ_CP064248:38979-39044 [Klebsiella pneumoniae]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References