Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 73642..74201 Replicon plasmid pLGM
Accession NZ_CP048631
Organism Ancylobacter pratisalsi strain DSM 102029

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag G3A50_RS21885 Protein ID WP_163078162.1
Coordinates 73908..74201 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G3A50_RS21880 Protein ID WP_163078159.1
Coordinates 73642..73911 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3A50_RS21865 68858..71992 + 3135 WP_163078429.1 efflux RND transporter permease subunit -
G3A50_RS21870 72390..73259 - 870 Protein_72 IS110 family transposase -
G3A50_RS21875 73240..73518 + 279 Protein_73 transposase -
G3A50_RS21880 73642..73911 + 270 WP_163078159.1 ribbon-helix-helix domain-containing protein Antitoxin
G3A50_RS21885 73908..74201 + 294 WP_163078162.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G3A50_RS21890 74390..74578 + 189 WP_163078432.1 hypothetical protein -
G3A50_RS21895 74892..75395 + 504 WP_163078165.1 sigma-70 family RNA polymerase sigma factor -
G3A50_RS21900 75506..76228 + 723 WP_163078168.1 FecR domain-containing protein -
G3A50_RS21905 76295..77161 - 867 WP_163078170.1 TniQ family protein -
G3A50_RS21910 77158..78039 - 882 WP_163078172.1 TniB family NTP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..159741 159741
- flank IS/Tn - - 73318..73518 200


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-45)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11416.03 Da        Isoelectric Point: 6.8719

>T149783 WP_163078162.1 NZ_CP048631:73908-74201 [Ancylobacter pratisalsi]
MKIQWTSKASSDLVRLHEHLSPVAPEAAARVVQQLAHAPDRLLDYPRIGEKLEAYEPREVRRIIVGNYEMRYEIANATIF
ILRLWHCRENRSFESEE

Download         Length: 294 bp

>T149783 NZ_CP064243:c7722-7447 [Klebsiella pneumoniae]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAATCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9872.29 Da        Isoelectric Point: 5.1312

>AT149783 WP_163078159.1 NZ_CP048631:73642-73911 [Ancylobacter pratisalsi]
MATETKVLTAHVPLGLAEKVEAMASRLERSRGWVMKQALAAWVDQEEERHRMTLEALEDVDAGRVIDHQAIQAWADSLGT
DKPLPAPVK

Download         Length: 270 bp

>AT149783 NZ_CP064243:c8006-7722 [Klebsiella pneumoniae]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References