Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 73642..74201 | Replicon | plasmid pLGM |
| Accession | NZ_CP048631 | ||
| Organism | Ancylobacter pratisalsi strain DSM 102029 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | G3A50_RS21885 | Protein ID | WP_163078162.1 |
| Coordinates | 73908..74201 (+) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | G3A50_RS21880 | Protein ID | WP_163078159.1 |
| Coordinates | 73642..73911 (+) | Length | 90 a.a. |
Genomic Context
Location: 68858..71992 (3135 bp)
Type: Others
Protein ID: WP_163078429.1
Type: Others
Protein ID: WP_163078429.1
Location: 73240..73518 (279 bp)
Type: Others
Protein ID: Protein_73
Type: Others
Protein ID: Protein_73
Location: 73642..73911 (270 bp)
Type: Antitoxin
Protein ID: WP_163078159.1
Type: Antitoxin
Protein ID: WP_163078159.1
Location: 73908..74201 (294 bp)
Type: Toxin
Protein ID: WP_163078162.1
Type: Toxin
Protein ID: WP_163078162.1
Location: 74390..74578 (189 bp)
Type: Others
Protein ID: WP_163078432.1
Type: Others
Protein ID: WP_163078432.1
Location: 74892..75395 (504 bp)
Type: Others
Protein ID: WP_163078165.1
Type: Others
Protein ID: WP_163078165.1
Location: 75506..76228 (723 bp)
Type: Others
Protein ID: WP_163078168.1
Type: Others
Protein ID: WP_163078168.1
Location: 72390..73259 (870 bp)
Type: Others
Protein ID: Protein_72
Type: Others
Protein ID: Protein_72
Location: 76295..77161 (867 bp)
Type: Others
Protein ID: WP_163078170.1
Type: Others
Protein ID: WP_163078170.1
Location: 77158..78039 (882 bp)
Type: Others
Protein ID: WP_163078172.1
Type: Others
Protein ID: WP_163078172.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G3A50_RS21865 | 68858..71992 | + | 3135 | WP_163078429.1 | efflux RND transporter permease subunit | - |
| G3A50_RS21870 | 72390..73259 | - | 870 | Protein_72 | IS110 family transposase | - |
| G3A50_RS21875 | 73240..73518 | + | 279 | Protein_73 | transposase | - |
| G3A50_RS21880 | 73642..73911 | + | 270 | WP_163078159.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| G3A50_RS21885 | 73908..74201 | + | 294 | WP_163078162.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| G3A50_RS21890 | 74390..74578 | + | 189 | WP_163078432.1 | hypothetical protein | - |
| G3A50_RS21895 | 74892..75395 | + | 504 | WP_163078165.1 | sigma-70 family RNA polymerase sigma factor | - |
| G3A50_RS21900 | 75506..76228 | + | 723 | WP_163078168.1 | FecR domain-containing protein | - |
| G3A50_RS21905 | 76295..77161 | - | 867 | WP_163078170.1 | TniQ family protein | - |
| G3A50_RS21910 | 77158..78039 | - | 882 | WP_163078172.1 | TniB family NTP-binding protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..159741 | 159741 | |
| - | flank | IS/Tn | - | - | 73318..73518 | 200 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11416.03 Da Isoelectric Point: 6.8719
>T149783 WP_163078162.1 NZ_CP048631:73908-74201 [Ancylobacter pratisalsi]
MKIQWTSKASSDLVRLHEHLSPVAPEAAARVVQQLAHAPDRLLDYPRIGEKLEAYEPREVRRIIVGNYEMRYEIANATIF
ILRLWHCRENRSFESEE
MKIQWTSKASSDLVRLHEHLSPVAPEAAARVVQQLAHAPDRLLDYPRIGEKLEAYEPREVRRIIVGNYEMRYEIANATIF
ILRLWHCRENRSFESEE
Download Length: 294 bp
>T149783 NZ_CP064243:c7722-7447 [Klebsiella pneumoniae]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAATCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAATCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
Antitoxin
Download Length: 90 a.a. Molecular weight: 9872.29 Da Isoelectric Point: 5.1312
>AT149783 WP_163078159.1 NZ_CP048631:73642-73911 [Ancylobacter pratisalsi]
MATETKVLTAHVPLGLAEKVEAMASRLERSRGWVMKQALAAWVDQEEERHRMTLEALEDVDAGRVIDHQAIQAWADSLGT
DKPLPAPVK
MATETKVLTAHVPLGLAEKVEAMASRLERSRGWVMKQALAAWVDQEEERHRMTLEALEDVDAGRVIDHQAIQAWADSLGT
DKPLPAPVK
Download Length: 270 bp
>AT149783 NZ_CP064243:c8006-7722 [Klebsiella pneumoniae]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA