Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 53370..54028 Replicon plasmid pLGM
Accession NZ_CP048631
Organism Ancylobacter pratisalsi strain DSM 102029

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G3A50_RS21780 Protein ID WP_163078121.1
Coordinates 53370..53774 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G3A50_RS21785 Protein ID WP_163078124.1
Coordinates 53774..54028 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3A50_RS21755 49103..50101 + 999 WP_163078106.1 plasmid partitioning protein RepB -
G3A50_RS21760 50290..51513 + 1224 WP_163078108.1 replication initiation protein RepC -
G3A50_RS21765 51585..51830 + 246 WP_163078111.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
G3A50_RS21770 51830..52267 + 438 WP_163078114.1 type II toxin-antitoxin system VapC family toxin -
G3A50_RS21775 52291..53370 - 1080 WP_163078117.1 site-specific integrase -
G3A50_RS21780 53370..53774 - 405 WP_163078121.1 type II toxin-antitoxin system VapC family toxin Toxin
G3A50_RS21785 53774..54028 - 255 WP_163078124.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G3A50_RS21790 54261..55217 + 957 WP_163078127.1 DUF1403 family protein -
G3A50_RS21795 55222..55932 + 711 WP_163078130.1 SMC-Scp complex subunit ScpB -
G3A50_RS21800 56197..56991 - 795 WP_163078133.1 IS21-like element helper ATPase IstB -
G3A50_RS21805 56981..58015 - 1035 Protein_59 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..159741 159741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-61)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14848.08 Da        Isoelectric Point: 6.9908

>T149782 WP_163078121.1 NZ_CP048631:c53774-53370 [Ancylobacter pratisalsi]
MYLVDTNVISEARRGSRPAIAWLRGIDPLSVHLSTLTLGEIMRGIALKQKADPKTAGHLAEWLRKLRHDHADRILPVTDP
ISVEWGRIAALRPRGDIDGLIAATAIVHDLILVTRNVKDFEDTGASFINPWDAD

Download         Length: 405 bp

>T149782 NZ_CP064242:154740-155051 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9146.27 Da        Isoelectric Point: 4.7420

>AT149782 WP_163078124.1 NZ_CP048631:c54028-53774 [Ancylobacter pratisalsi]
MEWPLQDAKNQFSRVVQKARTEGPQIVTLRGERAAVVLSAADYDTLRAGRPSLVDDLLSGPAWDADLAEAVERRASAPSR
DVAL

Download         Length: 255 bp

>AT149782 NZ_CP064242:155048-155467 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References