Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 26932..27508 | Replicon | plasmid pLGM |
| Accession | NZ_CP048631 | ||
| Organism | Ancylobacter pratisalsi strain DSM 102029 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | G3A50_RS21645 | Protein ID | WP_163078416.1 |
| Coordinates | 27176..27508 (+) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | G3A50_RS21640 | Protein ID | WP_163078061.1 |
| Coordinates | 26932..27174 (+) | Length | 81 a.a. |
Genomic Context
Location: 22593..23585 (993 bp)
Type: Others
Protein ID: WP_163078049.1
Type: Others
Protein ID: WP_163078049.1
Location: 23650..24438 (789 bp)
Type: Others
Protein ID: WP_163078052.1
Type: Others
Protein ID: WP_163078052.1
Location: 24435..25304 (870 bp)
Type: Others
Protein ID: WP_163078055.1
Type: Others
Protein ID: WP_163078055.1
Location: 25313..26623 (1311 bp)
Type: Others
Protein ID: WP_163078058.1
Type: Others
Protein ID: WP_163078058.1
Location: 26932..27174 (243 bp)
Type: Antitoxin
Protein ID: WP_163078061.1
Type: Antitoxin
Protein ID: WP_163078061.1
Location: 27176..27508 (333 bp)
Type: Toxin
Protein ID: WP_163078416.1
Type: Toxin
Protein ID: WP_163078416.1
Location: 27622..29895 (2274 bp)
Type: Others
Protein ID: WP_163078063.1
Type: Others
Protein ID: WP_163078063.1
Location: 29892..30956 (1065 bp)
Type: Others
Protein ID: WP_163078066.1
Type: Others
Protein ID: WP_163078066.1
Location: 30986..32143 (1158 bp)
Type: Others
Protein ID: WP_163078069.1
Type: Others
Protein ID: WP_163078069.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G3A50_RS21620 | 22593..23585 | + | 993 | WP_163078049.1 | taurine ABC transporter substrate-binding protein | - |
| G3A50_RS21625 | 23650..24438 | + | 789 | WP_163078052.1 | ATP-binding cassette domain-containing protein | - |
| G3A50_RS21630 | 24435..25304 | + | 870 | WP_163078055.1 | ABC transporter permease subunit | - |
| G3A50_RS21635 | 25313..26623 | + | 1311 | WP_163078058.1 | histidinol dehydrogenase | - |
| G3A50_RS21640 | 26932..27174 | + | 243 | WP_163078061.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| G3A50_RS21645 | 27176..27508 | + | 333 | WP_163078416.1 | endoribonuclease MazF | Toxin |
| G3A50_RS21650 | 27622..29895 | - | 2274 | WP_163078063.1 | recombinase RmuC | - |
| G3A50_RS21655 | 29892..30956 | - | 1065 | WP_163078066.1 | P-type DNA transfer ATPase VirB11 | - |
| G3A50_RS21660 | 30986..32143 | - | 1158 | WP_163078069.1 | type IV secretion system protein VirB10 | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..159741 | 159741 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 12194.06 Da Isoelectric Point: 9.6545
>T149781 WP_163078416.1 NZ_CP048631:27176-27508 [Ancylobacter pratisalsi]
VVAYVPEAGDIVWLQFSPQAGHEQAGHRLAVVLSPASYNRLGLILCCHLTTKRKGYPFEVPIEDERQVAVLADQVKSLDW
RIRAASFKGRISDSELAQVRAKARSLIGRP
VVAYVPEAGDIVWLQFSPQAGHEQAGHRLAVVLSPASYNRLGLILCCHLTTKRKGYPFEVPIEDERQVAVLADQVKSLDW
RIRAASFKGRISDSELAQVRAKARSLIGRP
Download Length: 333 bp
>T149781 NZ_CP064242:111223-111693 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8596.83 Da Isoelectric Point: 4.1813
>AT149781 WP_163078061.1 NZ_CP048631:26932-27174 [Ancylobacter pratisalsi]
MRAVVKKWGNSASVRIPAAMLAEAGLSLDQPVDIRSNNGAIIIEPIKSLEYDLDELIAAITPENMHEEVDIGEPAGKEAL
MRAVVKKWGNSASVRIPAAMLAEAGLSLDQPVDIRSNNGAIIIEPIKSLEYDLDELIAAITPENMHEEVDIGEPAGKEAL
Download Length: 243 bp
>AT149781 NZ_CP064242:110783-111226 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA