Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1584842..1585499 Replicon chromosome
Accession NZ_CP048621
Organism Providencia stuartii strain MF1

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T1H2A7
Locus tag G3A48_RS07025 Protein ID WP_036941148.1
Coordinates 1585089..1585499 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID B2Q1I8
Locus tag G3A48_RS07020 Protein ID WP_004921708.1
Coordinates 1584842..1585108 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3A48_RS07005 1579873..1582749 + 2877 WP_004921716.1 aminomethyl-transferring glycine dehydrogenase -
G3A48_RS07010 1582968..1583588 - 621 WP_004921714.1 HD domain-containing protein -
G3A48_RS07015 1583600..1584589 - 990 WP_004921711.1 tRNA-modifying protein YgfZ -
G3A48_RS07020 1584842..1585108 + 267 WP_004921708.1 FAD assembly factor SdhE Antitoxin
G3A48_RS07025 1585089..1585499 + 411 WP_036941148.1 membrane protein Toxin
G3A48_RS07030 1585545..1586063 - 519 WP_014656387.1 flavodoxin FldB -
G3A48_RS07035 1586226..1587149 + 924 WP_004921697.1 site-specific tyrosine recombinase XerD -
G3A48_RS07040 1587169..1587873 + 705 WP_004921696.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G3A48_RS07045 1587879..1589612 + 1734 WP_004921693.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15289.15 Da        Isoelectric Point: 10.8779

>T149775 WP_036941148.1 NZ_CP048621:1585089-1585499 [Providencia stuartii]
VVLWKSNLSISWKTQLFSTCAHGVVGFILLVAPWAPGNSMVWLPLLVIVIASWAKSQKSISKIKGTAVLVNGNKVQWKKN
EWSIVKQPWCSRVGVLLTLSALQGKPQKIRLWVAKDALSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

>T149775 NZ_CP064241:4104779-4104997 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10576.10 Da        Isoelectric Point: 4.9104

>AT149775 WP_004921708.1 NZ_CP048621:1584842-1585108 [Providencia stuartii]
MDIENKARIHWACRRGMRELDISIMPFFEYEYEGLSDKDKRTFVRLLECADPDLFNWLMNHGRPDDDELFGMVKLIQERN
KNRGPVEI

Download         Length: 267 bp

>AT149775 NZ_CP064241:4104378-4104752 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1H2A7

Antitoxin

Source ID Structure
AlphaFold DB A0A140NIX0

References