Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 871459..872291 Replicon chromosome
Accession NZ_CP048609
Organism Escherichia coli strain STEFF_1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P5UBZ5
Locus tag G3M66_RS04200 Protein ID WP_001094454.1
Coordinates 871459..871833 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3G8RJV8
Locus tag G3M66_RS04205 Protein ID WP_001320394.1
Coordinates 871923..872291 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3M66_RS04170 (866572) 866572..867720 - 1149 WP_000905922.1 capsule polysaccharide export inner-membrane protein KpsE -
G3M66_RS04175 (867792) 867792..868775 - 984 WP_248417863.1 KpsF/GutQ family sugar-phosphate isomerase -
G3M66_RS04180 (869586) 869586..869756 - 171 Protein_823 IS110 family transposase -
G3M66_RS04185 (870099) 870099..870668 - 570 WP_001290250.1 DUF4942 domain-containing protein -
G3M66_RS04190 (870765) 870765..870962 - 198 WP_000839276.1 DUF957 domain-containing protein -
G3M66_RS04195 (870974) 870974..871462 - 489 WP_000777545.1 DUF5983 family protein -
G3M66_RS04200 (871459) 871459..871833 - 375 WP_001094454.1 TA system toxin CbtA family protein Toxin
G3M66_RS04205 (871923) 871923..872291 - 369 WP_001320394.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
G3M66_RS04210 (872341) 872341..872984 - 644 Protein_829 antitoxin of toxin-antitoxin stability system -
G3M66_RS04215 (873003) 873003..873224 - 222 WP_000692300.1 DUF987 domain-containing protein -
G3M66_RS04220 (873287) 873287..873763 - 477 WP_001347688.1 RadC family protein -
G3M66_RS04225 (873779) 873779..874264 - 486 WP_029701480.1 antirestriction protein -
G3M66_RS04230 (874319) 874319..875137 - 819 WP_001234642.1 DUF932 domain-containing protein -
G3M66_RS04235 (875237) 875237..875470 - 234 WP_001119719.1 DUF905 family protein -
G3M66_RS04240 (875549) 875549..876004 - 456 WP_000581493.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14059.10 Da        Isoelectric Point: 9.2447

>T149737 WP_001094454.1 NZ_CP048609:c871833-871459 [Escherichia coli]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T149737 NZ_CP064232:2020967-2021069 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13623.22 Da        Isoelectric Point: 6.4783

>AT149737 WP_001320394.1 NZ_CP048609:c872291-871923 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT149737 NZ_CP064232:c2021076-2020931 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P5UBZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8RJV8

References