Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3441881..3442512 Replicon chromosome
Accession NZ_CP048605
Organism Escherichia coli strain PapRG-06-5

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9LJQ2
Locus tag G3M73_RS15910 Protein ID WP_001259387.1
Coordinates 3441881..3442156 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag G3M73_RS15915 Protein ID WP_000593555.1
Coordinates 3442153..3442512 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3M73_RS15895 3436885..3437952 + 1068 WP_000361491.1 HlyD family efflux transporter periplasmic adaptor subunit -
G3M73_RS15900 3437949..3440684 + 2736 WP_000149129.1 ribosome-associated ATPase/putative transporter RbbA -
G3M73_RS15905 3440684..3441808 + 1125 WP_001314210.1 ABC transporter permease -
G3M73_RS15910 3441881..3442156 + 276 WP_001259387.1 type II toxin-antitoxin system HicA family toxin Toxin
G3M73_RS15915 3442153..3442512 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G3M73_RS15920 3442562..3443422 - 861 WP_001131788.1 class II aldolase -
G3M73_RS15925 3443454..3443723 - 270 WP_000933061.1 HPr family phosphocarrier protein -
G3M73_RS15930 3443713..3445221 - 1509 WP_001298718.1 carbohydrate kinase -
G3M73_RS15935 3445214..3446572 - 1359 WP_001308116.1 PTS galactitol transporter subunit IIC -
G3M73_RS15940 3446649..3446930 - 282 WP_163425358.1 PTS sugar transporter subunit IIB -
G3M73_RS15945 3446927..3447400 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3433046..3442512 9466


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10214.91 Da        Isoelectric Point: 10.7076

>T149723 WP_001259387.1 NZ_CP048605:3441881-3442156 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESQVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T149723 NZ_CP064229:2020962-2021064 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT149723 WP_000593555.1 NZ_CP048605:3442153-3442512 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT149723 NZ_CP064229:c2021071-2020926 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LJQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References