Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2130959..2131746 | Replicon | chromosome |
| Accession | NZ_CP048605 | ||
| Organism | Escherichia coli strain PapRG-06-5 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A377E3D6 |
| Locus tag | G3M73_RS10080 | Protein ID | WP_001194695.1 |
| Coordinates | 2131369..2131746 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | G3M73_RS10075 | Protein ID | WP_163425221.1 |
| Coordinates | 2130959..2131318 (+) | Length | 120 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G3M73_RS10030 | 2126198..2126650 | + | 453 | WP_163425218.1 | hypothetical protein | - |
| G3M73_RS10035 | 2126647..2127099 | + | 453 | WP_163425219.1 | hypothetical protein | - |
| G3M73_RS10040 | 2127162..2127704 | + | 543 | WP_001104018.1 | DUF4339 domain-containing protein | - |
| G3M73_RS10045 | 2127764..2128216 | + | 453 | WP_020837115.1 | hypothetical protein | - |
| G3M73_RS10050 | 2128293..2128526 | + | 234 | WP_001114682.1 | DUF905 domain-containing protein | - |
| G3M73_RS10055 | 2128646..2129464 | + | 819 | WP_001234406.1 | DUF945 domain-containing protein | - |
| G3M73_RS10060 | 2129732..2130202 | + | 471 | WP_163425220.1 | antirestriction protein | - |
| G3M73_RS10065 | 2130214..2130693 | + | 480 | WP_000437750.1 | DNA repair protein RadC | - |
| G3M73_RS10070 | 2130714..2130935 | + | 222 | WP_000691981.1 | DUF987 domain-containing protein | - |
| G3M73_RS10075 | 2130959..2131318 | + | 360 | WP_163425221.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| G3M73_RS10080 | 2131369..2131746 | + | 378 | WP_001194695.1 | TA system toxin CbtA family protein | Toxin |
| G3M73_RS10085 | 2131743..2132234 | + | 492 | WP_000777682.1 | hypothetical protein | - |
| G3M73_RS10090 | 2132266..2132469 | + | 204 | WP_000413747.1 | DUF957 domain-containing protein | - |
| G3M73_RS10095 | 2132550..2133394 | + | 845 | Protein_1986 | DUF4942 domain-containing protein | - |
| G3M73_RS10105 | 2133736..2134467 | - | 732 | WP_001366128.1 | DNA polymerase III subunit epsilon | - |
| G3M73_RS10110 | 2134532..2134999 | + | 468 | WP_000917883.1 | ribonuclease HI | - |
| G3M73_RS10115 | 2134996..2135718 | - | 723 | WP_001307587.1 | class I SAM-dependent methyltransferase | - |
| G3M73_RS10120 | 2135752..2136507 | + | 756 | WP_137427674.1 | hydroxyacylglutathione hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE / gmhA/lpcA / hsiC1/vipB / hsiB1/vipA | 1975070..2136507 | 161437 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14180.97 Da Isoelectric Point: 7.4209
>T149718 WP_001194695.1 NZ_CP048605:2131369-2131746 [Escherichia coli]
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR
Download Length: 378 bp
>T149718 NZ_CP064227:c8041-7727 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13155.07 Da Isoelectric Point: 7.0261
>AT149718 WP_163425221.1 NZ_CP048605:2130959-2131318 [Escherichia coli]
MSNKIPTVNHDITEPWWGLKRSITPCFGARLVQSGNCLHYLADRASITGQFSDGDLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEVDSLGSHGYVYLAIYPTPAATA
MSNKIPTVNHDITEPWWGLKRSITPCFGARLVQSGNCLHYLADRASITGQFSDGDLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEVDSLGSHGYVYLAIYPTPAATA
Download Length: 360 bp
>AT149718 NZ_CP064227:c8307-8029 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|