Detailed information of TA system TA149713

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1054553..1055385
• Replicon: chromosome
• Accession: NZ_CP048605
• Organism: Escherichia coli strain PapRG-06-5

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: G3M73_RS05090
• Protein ID: WP_000854724.1
• Coordinates: 1054553..1054927 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: G3M73_RS05095
• Protein ID: WP_024210831.1
• Coordinates: 1055017..1055385 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G3M73_RS05050	1050138..1050692	-	555	WP_001001917.1	molecular chaperone YcdY	-
G3M73_RS05055	1050716..1051453	-	738	WP_000283664.1	zinc-binding phosphatase	-
G3M73_RS05060	1051508..1052446	-	939	WP_000351319.1	glyoxylate/hydroxypyruvate reductase GhrA	-
G3M73_RS05070	1052917..1053759	-	843	WP_005020348.1	DUF4942 domain-containing protein	-
G3M73_RS05075	1053856..1054053	-	198	WP_163425050.1	DUF957 domain-containing protein	-
G3M73_RS23120	1054065..1054556	-	492	Protein_1003	hypothetical protein	-
G3M73_RS05090	1054553..1054927	-	375	WP_000854724.1	TA system toxin CbtA family protein	Toxin
G3M73_RS05095	1055017..1055385	-	369	WP_024210831.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
G3M73_RS05100	1055465..1055687	-	223	Protein_1006	DUF987 domain-containing protein	-
G3M73_RS05105	1055750..1056226	-	477	WP_001383023.1	RadC family protein	-
G3M73_RS05110	1056242..1056721	-	480	WP_001383022.1	antirestriction protein	-
G3M73_RS05115	1057060..1057878	-	819	WP_137525578.1	DUF945 domain-containing protein	-
G3M73_RS05120	1057968..1058906	-	939	WP_000060628.1	hypothetical protein	-
G3M73_RS05125	1058972..1059382	-	411	WP_000642912.1	hypothetical protein	-
G3M73_RS05130	1059488..1059703	-	216	WP_000508161.1	hypothetical protein	-
G3M73_RS23125	1059716..1059862	-	147	WP_001383016.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	csgB / csgD / csgE / csgF / csgG	1045928..1085112	39184

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13989.99 Da
• Isoelectric Point: 8.2904

>T149713 WP_000854724.1 NZ_CP048605:c1054927-1054553 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLGRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPQAK

Nucleotide

• Length: 375 bp

>T149713 NZ_CP064225:c38920-38504 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13635.42 Da
• Isoelectric Point: 7.3992

>AT149713 WP_024210831.1 NZ_CP048605:c1055385-1055017 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGARLVQESNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSRGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT149713 NZ_CP064225:c39147-38917 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA