Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | itaRT/DUF1778(antitoxin) |
| Location | 1814740..1815577 | Replicon | chromosome |
| Accession | NZ_CP048604 | ||
| Organism | Escherichia coli strain PapRG-06-3 | ||
Toxin (Protein)
| Gene name | itaT | Uniprot ID | Q3Z4X7 |
| Locus tag | G3M72_RS08775 | Protein ID | WP_000227784.1 |
| Coordinates | 1815035..1815577 (+) | Length | 181 a.a. |
Antitoxin (Protein)
| Gene name | itaR | Uniprot ID | I2UQS9 |
| Locus tag | G3M72_RS08770 | Protein ID | WP_001297137.1 |
| Coordinates | 1814740..1815051 (+) | Length | 104 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G3M72_RS08745 | 1809760..1810707 | + | 948 | WP_001239441.1 | cytochrome o ubiquinol oxidase subunit II | - |
| G3M72_RS08750 | 1810729..1812720 | + | 1992 | WP_000467180.1 | cytochrome o ubiquinol oxidase subunit I | - |
| G3M72_RS08755 | 1812710..1813324 | + | 615 | WP_000179819.1 | cytochrome o ubiquinol oxidase subunit III | - |
| G3M72_RS08760 | 1813324..1813653 | + | 330 | WP_000019869.1 | cytochrome o ubiquinol oxidase subunit IV | - |
| G3M72_RS08765 | 1813665..1814555 | + | 891 | WP_001599477.1 | heme o synthase | - |
| G3M72_RS08770 | 1814740..1815051 | + | 312 | WP_001297137.1 | DUF1778 domain-containing protein | Antitoxin |
| G3M72_RS08775 | 1815035..1815577 | + | 543 | WP_000227784.1 | GNAT family N-acetyltransferase | Toxin |
| G3M72_RS08780 | 1815633..1816568 | - | 936 | WP_001297127.1 | sel1 repeat family protein | - |
| G3M72_RS08785 | 1816976..1818340 | + | 1365 | WP_001000978.1 | MFS transporter | - |
| G3M72_RS08790 | 1818468..1818959 | - | 492 | WP_001138904.1 | nucleotide binding protein YajQ | - |
| G3M72_RS08795 | 1819127..1820038 | + | 912 | WP_000705853.1 | 2-dehydropantoate 2-reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 181 a.a. Molecular weight: 19805.02 Da Isoelectric Point: 8.3395
>T149695 WP_000227784.1 NZ_CP048604:1815035-1815577 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA
Download Length: 543 bp
>T149695 NZ_CP064220:c1011-862 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 104 a.a. Molecular weight: 11358.04 Da Isoelectric Point: 10.4825
>AT149695 WP_001297137.1 NZ_CP048604:1814740-1815051 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA
Download Length: 312 bp
>AT149695 NZ_CP064220:1056-1115 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|