Detailed information of TA system TA149656

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 822971..823805
• Replicon: chromosome
• Accession: NZ_CP048603
• Organism: Escherichia coli strain ChlosBP-23-1

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A2T3TJB4
• Locus tag: G3M71_RS03915
• Protein ID: WP_000854811.1
• Coordinates: 822971..823348 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A2T3TJJ3
• Locus tag: G3M71_RS03920
• Protein ID: WP_001285590.1
• Coordinates: 823437..823805 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G3M71_RS03895	820769..821989	+	1221	WP_000794251.1	capsular biosynthesis protein	-
G3M71_RS03900	822012..822248	-	237	WP_000986719.1	hypothetical protein	-
G3M71_RS03905	822351..822527	-	177	WP_000839288.1	DUF957 domain-containing protein	-
G3M71_RS03910	822544..822974	-	431	Protein_767	hypothetical protein	-
G3M71_RS03915	822971..823348	-	378	WP_000854811.1	type IV toxin-antitoxin system toxin CbtA	Toxin
G3M71_RS03920	823437..823805	-	369	WP_001285590.1	type IV toxin-antitoxin system toxin CbtA	Antitoxin
G3M71_RS03925	823879..824100	-	222	WP_000692300.1	DUF987 domain-containing protein	-
G3M71_RS03930	824169..824645	-	477	WP_001186725.1	RadC family protein	-
G3M71_RS03935	824661..825146	-	486	WP_000214310.1	antirestriction protein	-
G3M71_RS03940	825238..826056	-	819	WP_001234593.1	DUF945 domain-containing protein	-
G3M71_RS03945	826211..826345	-	135	WP_032144430.1	DUF905 family protein	-
G3M71_RS03950	826446..826901	-	456	WP_000581502.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	ugd / kpsS	800671..835193	34522

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14041.14 Da
• Isoelectric Point: 7.8839

>T149656 WP_000854811.1 NZ_CP048603:c823348-822971 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Nucleotide

• Length: 378 bp

>T149656 NZ_CP064209:c51261-50791 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13608.50 Da
• Isoelectric Point: 6.6242

>AT149656 WP_001285590.1 NZ_CP048603:c823805-823437 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLYSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Nucleotide

• Length: 369 bp

>AT149656 NZ_CP064209:c51701-51258 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Toxin

• AlphaFold DB: A0A2T3TJB4

Antitoxin

• AlphaFold DB: A0A2T3TJJ3