149646

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1326743..1327308 Replicon chromosome
Accession NZ_CP048600
Organism Helicobacter pylori strain GCT 43

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag G3M68_RS06245 Protein ID WP_163498199.1
Coordinates 1326743..1327009 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G3M68_RS06250 Protein ID WP_163498200.1
Coordinates 1327057..1327308 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3M68_RS06230 1322847..1324022 - 1176 WP_001931042.1 sugar transporter -
G3M68_RS06235 1324300..1325043 + 744 WP_108565105.1 carbonic anhydrase -
G3M68_RS06240 1326388..1326762 + 375 WP_163498198.1 hypothetical protein -
G3M68_RS06245 1326743..1327009 + 267 WP_163498199.1 type II toxin-antitoxin system YafQ family toxin Toxin
G3M68_RS06250 1327057..1327308 + 252 WP_163498200.1 hypothetical protein Antitoxin
G3M68_RS06255 1327906..1328169 + 264 WP_163498201.1 hypothetical protein -
G3M68_RS06260 1328178..1328480 + 303 WP_163498202.1 type II toxin-antitoxin system YafQ family toxin -
G3M68_RS06265 1328559..1329083 - 525 WP_001135604.1 acyl-CoA thioesterase -
G3M68_RS06270 1329223..1330071 + 849 WP_163498203.1 SDR family oxidoreductase -
G3M68_RS06275 1330064..1331044 + 981 WP_000921470.1 iron ABC transporter permease -
G3M68_RS06280 1331044..1331811 + 768 WP_163498204.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10341.30 Da        Isoelectric Point: 9.5330

>T149646 WP_163498199.1 NZ_CP048600:1326743-1327009 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILTLRKKEPLPQPFKDHALKGVWKPYRECHIKPDILLVYLVKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T149646 NZ_CP064208:327908-328276 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACTGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9561.63 Da        Isoelectric Point: 4.7953

>AT149646 WP_163498200.1 NZ_CP048600:1327057-1327308 [Helicobacter pylori]
MPNTTNKDYTKYSQKQLFNLINQLEQKISQAFDDKRGCCLGHEIPNLETQQAMREALNGENLEVIGDFSAWANERKKEVN
AEN

Download         Length: 252 bp

>AT149646 NZ_CP064208:327690-327911 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References