Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4347751..4348490 Replicon chromosome
Accession NZ_CP048598
Organism Klebsiella aerogenes strain AUH-KAM-9

Toxin (Protein)


Gene name tacT Uniprot ID A0A7D7FM44
Locus tag F8267_RS20475 Protein ID WP_026612320.1
Coordinates 4347751..4348236 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag F8267_RS20480 Protein ID WP_015705366.1
Coordinates 4348224..4348490 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8267_RS20455 4343298..4344368 - 1071 WP_045365882.1 mannonate dehydratase -
F8267_RS20460 4344629..4344787 + 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
F8267_RS20465 4344844..4345944 - 1101 WP_015366663.1 NADH:flavin oxidoreductase/NADH oxidase -
F8267_RS20470 4346063..4347679 - 1617 WP_048230873.1 FAD-NAD(P)-binding protein -
F8267_RS20475 4347751..4348236 - 486 WP_026612320.1 GNAT family N-acetyltransferase Toxin
F8267_RS20480 4348224..4348490 - 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
F8267_RS20485 4348763..4349998 + 1236 WP_020078885.1 MFS transporter -
F8267_RS20490 4350042..4350539 - 498 WP_047076455.1 heme-binding protein -
F8267_RS20495 4350635..4351252 - 618 WP_032711621.1 response regulator transcription factor -
F8267_RS20500 4351252..4352571 - 1320 WP_048230874.1 two-component sensor histidine kinase -
F8267_RS20505 4352568..4353155 - 588 WP_048230875.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(25-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17591.26 Da        Isoelectric Point: 8.8793

>T149640 WP_026612320.1 NZ_CP048598:c4348236-4347751 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGMKNQAQGAARTFVVCKEDSHQVVGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T149640 NZ_CP064205:c4755994-4755461 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCTGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT149640 WP_015705366.1 NZ_CP048598:c4348490-4348224 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT149640 NZ_CP064205:c4756271-4756005 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D7FM44

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References