Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1499667..1500253 Replicon chromosome
Accession NZ_CP048598
Organism Klebsiella aerogenes strain AUH-KAM-9

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag F8267_RS07195 Protein ID WP_002920800.1
Coordinates 1499667..1500035 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag F8267_RS07200 Protein ID WP_004174006.1
Coordinates 1500032..1500253 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8267_RS07175 1495152..1496222 - 1071 WP_048231406.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
F8267_RS07180 1496224..1497069 - 846 WP_015369329.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
F8267_RS07185 1497066..1497953 - 888 WP_047042947.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
F8267_RS07190 1498060..1499376 - 1317 WP_047042950.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
F8267_RS07195 1499667..1500035 - 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
F8267_RS07200 1500032..1500253 - 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F8267_RS07205 1500417..1501130 - 714 WP_086538103.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
F8267_RS07210 1501148..1501915 - 768 WP_015369325.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
F8267_RS07215 1501912..1503189 - 1278 WP_015369324.1 branched chain amino acid ABC transporter permease LivM -
F8267_RS07220 1503186..1504112 - 927 WP_015369323.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1494415..1505275 10860


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T149637 WP_002920800.1 NZ_CP048598:c1500035-1499667 [Klebsiella aerogenes]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T149637 NZ_CP064205:2084166-2084268 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT149637 WP_004174006.1 NZ_CP048598:c1500253-1500032 [Klebsiella aerogenes]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT149637 NZ_CP064205:c2084275-2084130 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References