Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 982850..983507 Replicon chromosome
Accession NZ_CP048598
Organism Klebsiella aerogenes strain AUH-KAM-9

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag F8267_RS04630 Protein ID WP_015369792.1
Coordinates 982850..983260 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag F8267_RS04635 Protein ID WP_015369791.1
Coordinates 983241..983507 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8267_RS04610 978849..980582 - 1734 WP_163359212.1 single-stranded-DNA-specific exonuclease RecJ -
F8267_RS04615 980588..981301 - 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F8267_RS04620 981324..982220 - 897 WP_045363589.1 site-specific tyrosine recombinase XerD -
F8267_RS04625 982321..982842 + 522 WP_015369793.1 flavodoxin FldB -
F8267_RS04630 982850..983260 - 411 WP_015369792.1 protein YgfX Toxin
F8267_RS04635 983241..983507 - 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
F8267_RS04640 983731..984714 + 984 WP_015369790.1 tRNA-modifying protein YgfZ -
F8267_RS04645 984813..985472 - 660 WP_008806429.1 hemolysin III family protein -
F8267_RS04650 985637..985948 - 312 WP_015703422.1 N(4)-acetylcytidine aminohydrolase -
F8267_RS04655 985999..986727 + 729 WP_015369788.1 MurR/RpiR family transcriptional regulator -
F8267_RS04660 986847..988280 + 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T149636 WP_015369792.1 NZ_CP048598:c983260-982850 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T149636 NZ_CP064205:797928-798338 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT149636 WP_015369791.1 NZ_CP048598:c983507-983241 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT149636 NZ_CP064205:797681-797947 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References