Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2087931..2088537 Replicon chromosome
Accession NZ_CP048589
Organism Agrobacterium tumefaciens strain But002

Toxin (Protein)


Gene name PumA Uniprot ID A0A822UZY8
Locus tag FY129_RS10470 Protein ID WP_020011654.1
Coordinates 2087931..2088227 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag FY129_RS10475 Protein ID WP_004429917.1
Coordinates 2088232..2088537 (+) Length 102 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY129_RS10435 (FY129_10365) 2083525..2083872 + 348 WP_004429958.1 antibiotic biosynthesis monooxygenase -
FY129_RS10440 (FY129_10370) 2083882..2084406 + 525 WP_004429943.1 heme utilization cystosolic carrier protein HutX -
FY129_RS10445 (FY129_10375) 2084591..2084980 + 390 WP_262576100.1 hypothetical protein -
FY129_RS10450 (FY129_10380) 2085133..2085672 + 540 WP_004429935.1 DUF2975 domain-containing protein -
FY129_RS10455 (FY129_10385) 2085682..2085924 + 243 WP_004429931.1 helix-turn-helix transcriptional regulator -
FY129_RS10460 (FY129_10390) 2086018..2086794 + 777 WP_004429927.1 YbaY family lipoprotein -
FY129_RS10465 (FY129_10395) 2087001..2087885 + 885 WP_112978057.1 formyltetrahydrofolate deformylase -
FY129_RS10470 (FY129_10400) 2087931..2088227 + 297 WP_020011654.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FY129_RS10475 (FY129_10405) 2088232..2088537 + 306 WP_004429917.1 putative addiction module antidote protein Antitoxin
FY129_RS10480 (FY129_10410) 2088551..2089945 - 1395 WP_262576101.1 sensor histidine kinase -
FY129_RS10485 (FY129_10415) 2089942..2090622 - 681 WP_003491888.1 response regulator transcription factor -
FY129_RS10490 (FY129_10420) 2090704..2091771 + 1068 WP_051091653.1 ABC transporter substrate-binding protein -
FY129_RS10495 (FY129_10425) 2092197..2093141 + 945 WP_020011659.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 10888.61 Da        Isoelectric Point: 10.2733

>T149635 WP_020011654.1 NZ_CP048589:2087931-2088227 [Agrobacterium tumefaciens]
MLTIRETSEFADWLAGLRDVQARARIARRIYRLADGNPGDVKPVGEGVSELRIDLGPGYRVYFVRHGDVVIILLCGGDKA
SQPRDIARAKKLARALKE

Download         Length: 297 bp

>T149635 NZ_CP064205:732163-732648 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATTCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10592.90 Da        Isoelectric Point: 4.5580

>AT149635 WP_004429917.1 NZ_CP048589:2088232-2088537 [Agrobacterium tumefaciens]
MPLVTRDYDAARYLDSDESLAAYIADATESGDAQELAHALGVVARAKGMTDLSRQTGLPRQTLYKALSGEGNPELATIAK
VADALGYRLSLVAKPPADTAA

Download         Length: 306 bp

>AT149635 NZ_CP064205:731873-732166 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A822UZY8


Antitoxin

Source ID Structure

References