Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 486314..486908 Replicon chromosome
Accession NZ_CP048589
Organism Agrobacterium tumefaciens strain But002

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag FY129_RS02360 Protein ID WP_080865974.1
Coordinates 486594..486908 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FY129_RS02355 Protein ID WP_080865973.1
Coordinates 486314..486613 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY129_RS02330 (FY129_02335) 481501..482499 + 999 WP_060723902.1 asparaginase -
FY129_RS02335 (FY129_02340) 482634..483254 + 621 WP_078051121.1 glutathione S-transferase family protein -
FY129_RS02340 (FY129_02345) 483348..484007 - 660 WP_003508979.1 glutathione S-transferase family protein -
FY129_RS02345 (FY129_02350) 484090..484605 - 516 WP_112293084.1 MarR family transcriptional regulator -
FY129_RS02350 (FY129_02355) 484748..486277 + 1530 WP_031234516.1 MDR family MFS transporter -
FY129_RS02355 (FY129_02360) 486314..486613 - 300 WP_080865973.1 putative addiction module antidote protein Antitoxin
FY129_RS02360 (FY129_02365) 486594..486908 - 315 WP_080865974.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FY129_RS02365 (FY129_02370) 487139..488155 + 1017 WP_262576280.1 ligase-associated DNA damage response exonuclease -
FY129_RS02370 (FY129_02375) 488157..489782 + 1626 WP_099085579.1 cisplatin damage response ATP-dependent DNA ligase -
FY129_RS02375 (FY129_02380) 489957..490922 + 966 WP_020813204.1 alpha/beta fold hydrolase -
FY129_RS02380 (FY129_02385) 490961..491743 - 783 WP_003508963.1 glycosyltransferase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-95)

Antitoxin

Uncharacterized protein HI1420

(6-97)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11772.48 Da        Isoelectric Point: 10.3857

>T149634 WP_080865974.1 NZ_CP048589:c486908-486594 [Agrobacterium tumefaciens]
MNSFQKSAEFDEWLKVLKDRAGKVRILHRLTAAEHGNFGDCAPVGEGVSEMRIHFGPGYRVYFTRVGKRVYFLLVGGDKS
SQRRDIKRAIEMAQTIGRDGRDGI

Download         Length: 315 bp

>T149634 NZ_CP064205:327907-328275 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACTGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10765.29 Da        Isoelectric Point: 4.8307

>AT149634 WP_080865973.1 NZ_CP048589:c486613-486314 [Agrobacterium tumefaciens]
MAVTEFSKFDVSDYLDSDEAMIEFLAIAMEDENPDVFIGALGAVAKARGMSHIADASGLGRESLYKALRPGSKLRYETVQ
RVLHALGFRLAVEKSLNAA

Download         Length: 300 bp

>AT149634 NZ_CP064205:327689-327910 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References