Detailed information of TA system TA149633

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 441511..442055
• Replicon: chromosome
• Accession: NZ_CP048589
• Organism: Agrobacterium tumefaciens strain But002

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FY129_RS02140
• Protein ID: WP_026363704.1
• Coordinates: 441765..442055 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A822V4A8
• Locus tag: FY129_RS02135
• Protein ID: WP_003509084.1
• Coordinates: 441511..441762 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY129_RS02115 (FY129_02115)	437273..437953	+	681	WP_003509096.1	GntR family transcriptional regulator	-
FY129_RS02120 (FY129_02120)	437999..438475	+	477	WP_099085593.1	DUF1284 domain-containing protein	-
FY129_RS02125 (FY129_02125)	438651..439751	-	1101	WP_099085592.1	hypothetical protein	-
FY129_RS02130 (FY129_02130)	439988..441133	+	1146	WP_020010628.1	site-specific DNA-methyltransferase	-
FY129_RS02135 (FY129_02135)	441511..441762	+	252	WP_003509084.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FY129_RS02140 (FY129_02140)	441765..442055	+	291	WP_026363704.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FY129_RS02145 (FY129_02145)	442097..442708	-	612	WP_003509082.1	HAD family phosphatase	-
FY129_RS02150 (FY129_02150)	442705..443817	-	1113	WP_020812857.1	A/G-specific adenine glycosylase	-
FY129_RS02155 (FY129_02155)	443945..444409	+	465	WP_020812858.1	hypothetical protein	-
FY129_RS02160 (FY129_02160)	444437..444958	+	522	WP_003509079.1	DUF721 domain-containing protein	-
FY129_RS02165 (FY129_02165)	445087..445767	+	681	WP_003509078.1	DsbA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (12-70)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11195.86 Da
• Isoelectric Point: 6.2182

>T149633 WP_026363704.1 NZ_CP048589:441765-442055 [Agrobacterium tumefaciens]
VGFRLSLLAEEDVIRIAEEGIAIFGLAQAQKYHRELYEIFELISLNPRMARERHELLPPLRIHRFRAHLVVYGVGADDDV
LIVRVRHAHEDWVNES

Nucleotide

• Length: 291 bp

>T149633 NZ_CP064203:3936455-3936844 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9339.55 Da
• Isoelectric Point: 9.7317

>AT149633 WP_003509084.1 NZ_CP048589:441511-441762 [Agrobacterium tumefaciens]
MATMNISLPAPMKEWVEAQSRTGRYSNASDYVRDLIRKDQERGEKIAAMQHFVDEGLQSGAGHRSQQALFAEAEARSMKR
KIG

Nucleotide

• Length: 252 bp

>AT149633 NZ_CP064203:3936191-3936448 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A822V4A8