Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 80535..81115 | Replicon | plasmid pAt1 |
| Accession | NZ_CP048586 | ||
| Organism | Agrobacterium pusense strain CC001 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | FY130_RS23635 | Protein ID | WP_262622951.1 |
| Coordinates | 80535..80918 (-) | Length | 128 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | FY130_RS23640 | Protein ID | WP_262622952.1 |
| Coordinates | 80915..81115 (-) | Length | 67 a.a. |
Genomic Context
Location: 78600..79514 (915 bp)
Type: Others
Protein ID: WP_262622950.1
Type: Others
Protein ID: WP_262622950.1
Location: 76201..76809 (609 bp)
Type: Others
Protein ID: WP_111815102.1
Type: Others
Protein ID: WP_111815102.1
Location: 76980..77576 (597 bp)
Type: Others
Protein ID: WP_111815104.1
Type: Others
Protein ID: WP_111815104.1
Location: 77603..78499 (897 bp)
Type: Others
Protein ID: WP_262622949.1
Type: Others
Protein ID: WP_262622949.1
Location: 79636..80067 (432 bp)
Type: Others
Protein ID: WP_044460075.1
Type: Others
Protein ID: WP_044460075.1
Location: 80067..80366 (300 bp)
Type: Others
Protein ID: WP_082055481.1
Type: Others
Protein ID: WP_082055481.1
Location: 80535..80918 (384 bp)
Type: Toxin
Protein ID: WP_262622951.1
Type: Toxin
Protein ID: WP_262622951.1
Location: 80915..81115 (201 bp)
Type: Antitoxin
Protein ID: WP_262622952.1
Type: Antitoxin
Protein ID: WP_262622952.1
Location: 81310..83670 (2361 bp)
Type: Others
Protein ID: WP_262622953.1
Type: Others
Protein ID: WP_262622953.1
Location: 83957..84397 (441 bp)
Type: Others
Protein ID: WP_234942636.1
Type: Others
Protein ID: WP_234942636.1
Location: 84387..84833 (447 bp)
Type: Others
Protein ID: WP_262622954.1
Type: Others
Protein ID: WP_262622954.1
Location: 85012..85494 (483 bp)
Type: Others
Protein ID: Protein_91
Type: Others
Protein ID: Protein_91
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FY130_RS23605 (FY130_23430) | 76201..76809 | - | 609 | WP_111815102.1 | NAD(P)H:quinone oxidoreductase | - |
| FY130_RS23610 (FY130_23435) | 76980..77576 | - | 597 | WP_111815104.1 | NADPH-dependent F420 reductase | - |
| FY130_RS23615 (FY130_23440) | 77603..78499 | - | 897 | WP_262622949.1 | pirin family protein | - |
| FY130_RS23620 (FY130_23445) | 78600..79514 | + | 915 | WP_262622950.1 | LysR family transcriptional regulator | - |
| FY130_RS23625 (FY130_23450) | 79636..80067 | - | 432 | WP_044460075.1 | type II toxin-antitoxin system VapC family toxin | - |
| FY130_RS23630 (FY130_23455) | 80067..80366 | - | 300 | WP_082055481.1 | hypothetical protein | - |
| FY130_RS23635 (FY130_23460) | 80535..80918 | - | 384 | WP_262622951.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| FY130_RS23640 (FY130_23465) | 80915..81115 | - | 201 | WP_262622952.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| FY130_RS23645 (FY130_23470) | 81310..83670 | - | 2361 | WP_262622953.1 | hypothetical protein | - |
| FY130_RS23650 (FY130_23475) | 83957..84397 | - | 441 | WP_234942636.1 | PIN domain-containing protein | - |
| FY130_RS23655 (FY130_23480) | 84387..84833 | - | 447 | WP_262622954.1 | DNA-binding protein | - |
| FY130_RS23660 (FY130_23485) | 85012..85494 | - | 483 | Protein_91 | LysR substrate-binding domain-containing protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | gmd / htpB | 1..426589 | 426589 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14102.30 Da Isoelectric Point: 6.9166
>T149628 WP_262622951.1 NZ_CP048586:c80918-80535 [Agrobacterium pusense]
VILVDSSIWIDHFRHVEPELVKIIGDDQLLCHPFVVGELALGSLRERDAVLAFLTAQREAVVATHAEVMTVIDRHSIFSM
GIGYTDAHLLTSTLLDRRSSLWTRDKRLAAAARKAGAALYLSPHIPH
VILVDSSIWIDHFRHVEPELVKIIGDDQLLCHPFVVGELALGSLRERDAVLAFLTAQREAVVATHAEVMTVIDRHSIFSM
GIGYTDAHLLTSTLLDRRSSLWTRDKRLAAAARKAGAALYLSPHIPH
Download Length: 384 bp
>T149628 NZ_CP064193:6632-6919 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
Antitoxin
Download Length: 67 a.a. Molecular weight: 7195.35 Da Isoelectric Point: 11.4483
>AT149628 WP_262622952.1 NZ_CP048586:c81115-80915 [Agrobacterium pusense]
MRSTINLDDSLMERAKSLTGTKETAALVRQALETLVRVESGKRLIALGGTMPEAEAAPRRRSGVRK
MRSTINLDDSLMERAKSLTGTKETAALVRQALETLVRVESGKRLIALGGTMPEAEAAPRRRSGVRK
Download Length: 201 bp
>AT149628 NZ_CP064193:6906-7220 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA