Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 902014..903537 Replicon chromosome
Accession NZ_CP048565
Organism Agrobacterium tumefaciens strain Gle002

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag FY133_RS18445 Protein ID WP_262514616.1
Coordinates 902293..903537 (+) Length 415 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag FY133_RS18440 Protein ID WP_262514615.1
Coordinates 902014..902280 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY133_RS18420 (FY133_18320) 897173..898114 + 942 WP_080867003.1 sugar phosphate isomerase/epimerase -
FY133_RS18425 (FY133_18325) 898170..899099 + 930 WP_112489079.1 TIM barrel protein -
FY133_RS18430 (FY133_18330) 899269..900984 + 1716 WP_262563467.1 AIPR family protein -
FY133_RS18435 (FY133_18335) 901367..901642 + 276 WP_262563468.1 hypothetical protein -
FY133_RS18440 (FY133_18340) 902014..902280 + 267 WP_262514615.1 helix-turn-helix transcriptional regulator Antitoxin
FY133_RS18445 (FY133_18345) 902293..903537 + 1245 WP_262514616.1 type II toxin-antitoxin system HipA family toxin Toxin
FY133_RS18450 (FY133_18350) 904020..905129 + 1110 WP_262514617.1 hypothetical protein -
FY133_RS18455 (FY133_18355) 905656..906564 + 909 WP_262514618.1 hypothetical protein -
FY133_RS18460 (FY133_18360) 906648..907067 + 420 WP_262514619.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(16-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 415 a.a.        Molecular weight: 45818.30 Da        Isoelectric Point: 6.6937

>T149622 WP_262514616.1 NZ_CP048565:902293-903537 [Agrobacterium tumefaciens]
VTTIFYESLPVANLIDRDGISLAYEPSWEQRASAFPISLTMPLRSGTYGAEQVMPWLANLLPETHLSEIGQQLKVSPQDI
VGLLTRLGRDTAGAFSIGEPRRDGNNFRVVPDEAALERILNELPERPFLVGEQGVSMSLAGVQDKLPVYLAEDGKIAIPV
DGTPSTHILKPDIRRLTSSVQNEAFCMTLARLCELETAEVTTGRAGSRDYLLVKRYDRIADAEGTIRRVHQEDFCQLLGL
FPSEKYERTGLGQRGGASLVHMFEALARYVSPAERLKLLDAVMFNILICNSDSHAKNYSVLVGAAGTAKLAPLYDLMCAA
VYKQVDQSLPQQIATKSNANELHGNDWRQFASAVGLSPAVVTKRIRELSDRVASKLEEALGETERHPSFHRDFGENLRFL
IRKRCQRIGRQAVG

Download         Length: 1245 bp

>T149622 NZ_CP064191:307004-307312 [Rhizobium sp. 007]
ATGGCATTGGAAACAACGCGCTTCGATATTCAGAACTACATCAAAAGTCACGAGGATCAGACTGGCTATCTCGACGCTGT
TCTGGAGGATGGAGATCCTGCTCTTATTGCAGCGGCCATCGGCGATATTGCCCGCGCACGCGGCGCATCACAATTCGCGA
AAGACAGCGGACTCAGTCGTGAAACCATCTATAAGGTTTTTCGCCCAGGGGGAAACCCGACGCTCGATACGATCGCCAAA
GCGGTGAAAGTGCTTGGCCTGCGGCTGTCGCTGGTACCGGCATCCAACTCCACCAAAGGCCCGATCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9620.86 Da        Isoelectric Point: 5.8324

>AT149622 WP_262514615.1 NZ_CP048565:902014-902280 [Agrobacterium tumefaciens]
MIRSAAEFGALVREHRKKQGWTQTQLAERCGTGERFIVDLENGKPSCQLEKSLIAARTVGIDLGDLKTASPPATSEADDD
LGYLPRFS

Download         Length: 267 bp

>AT149622 NZ_CP064191:306712-307002 [Rhizobium sp. 007]
ATGATTGAAGTTCGACTGACAGTCGTTTTTTCCCGATGGCTGGAAGATCTCAAAGACCGGCGCGCGCGTGACAGAGTTCT
CGCCAGATTGCGCCGTTTCGAATTAGAAAATTTCGGAGACGCAAAGCCCGTGGGGAGCGGGGTGAGCGAGGCACGAATAG
ATTATGGGCCGGGGTATCGCCTATATTTTGTGAGGCAGGCTGATGTTGTCGTGGTGATGCTGTGTGGTGGCGACAAAGCA
AGCCAGAAACGCGACATAGCGACGGCGAAGGCAATGGCGAAGGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References