Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 648691..649298 Replicon chromosome
Accession NZ_CP048564
Organism Agrobacterium tumefaciens strain Gle002

Toxin (Protein)


Gene name relE Uniprot ID A0A1S7Q870
Locus tag FY133_RS03225 Protein ID WP_031234113.1
Coordinates 648691..649026 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A822V573
Locus tag FY133_RS03230 Protein ID WP_020811442.1
Coordinates 649023..649298 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY133_RS03210 (FY133_03200) 644744..646936 - 2193 WP_003509229.1 transglycosylase domain-containing protein -
FY133_RS03215 (FY133_03205) 647191..647670 + 480 WP_003509227.1 YcgN family cysteine cluster protein -
FY133_RS03220 (FY133_03210) 647839..648663 + 825 WP_003509224.1 class D beta-lactamase -
FY133_RS03225 (FY133_03215) 648691..649026 - 336 WP_031234113.1 type II toxin-antitoxin system YafQ family toxin Toxin
FY133_RS03230 (FY133_03220) 649023..649298 - 276 WP_020811442.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FY133_RS03235 649297..649461 + 165 WP_153463487.1 hypothetical protein -
FY133_RS03240 (FY133_03225) 649511..652090 + 2580 WP_262514292.1 heavy metal translocating P-type ATPase -
FY133_RS03245 (FY133_03230) 652087..652509 + 423 WP_003509219.1 Cu(I)-responsive transcriptional regulator -
FY133_RS03250 (FY133_03235) 652562..652762 + 201 WP_003509218.1 heavy-metal-associated domain-containing protein -
FY133_RS03255 (FY133_03240) 652839..653108 + 270 WP_003509217.1 type II toxin-antitoxin system ParD family antitoxin -
FY133_RS03260 (FY133_03245) 653098..653463 + 366 WP_112277691.1 type II toxin-antitoxin system RelE/ParE family toxin -
FY133_RS03265 (FY133_03250) 653460..653708 - 249 WP_003509215.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(24-110)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12959.82 Da        Isoelectric Point: 8.9995

>T149620 WP_031234113.1 NZ_CP048564:c649026-648691 [Agrobacterium tumefaciens]
VTDKKGHGKEAASKRTVLPRSSDFTRQFIKDWQRLNNSGRYDMVKLKEIMLLLIANEAPLPAQFRDHELTGEWHDHRECH
VGGDFLLIYKLDEKQNLLIFTRAGTHAELFR

Download         Length: 336 bp

>T149620 NZ_CP064191:279884-280285 [Rhizobium sp. 007]
TTGACGCGCTATCTGCTCGATACGAACATCATCAGCGATCTCGTGCGCAATCCTGGTGGGCTAGCAACGAAGCATCTGCA
GCGCGCCGGCGACGAGAACGTTTGCACCAGCATCATCGTCGCGGCCGAGTTGCGATACGGATGCGCAAAGAAGGGTTCGG
CCAAGCTTCTGGAACGGGTAGAGGAGGTCTTGTCGGCAATTCCAGTCCTTGCACTGGAGGGTCCCGCGGACATCGTCTAC
GGCTCGATCCGTGCCACTCTCGAGCGGGAAGGGCGGACCGTTGGCCACAACGGCCTGCTGATCGCCGCGCATGCCTCCTC
TCTCGGCACAACATTGGTGACTGCCAATGTTGGCGAGTTCAGCAGAATACCTGACCTGACAATTGAGAACTGGATCGAAT
GA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9930.42 Da        Isoelectric Point: 8.6855

>AT149620 WP_020811442.1 NZ_CP048564:c649298-649023 [Agrobacterium tumefaciens]
MTANAYVRARIDQALKDDATAVLDSLGLTVSDVMRMMLTRIAREKALPIELTQPNAETLAAIEEARAIAAARRNRFGTAQ
ALFDALDGNKR

Download         Length: 276 bp

>AT149620 NZ_CP064191:279633-279887 [Rhizobium sp. 007]
ATGGTTCACGCACATCAGCCGGATTCGAAGGAGGTTCGGCTATTTCGTAATAACCGCAGCCAGGCTATTCGAATTCCGGC
CGAATTCGAGCTCCCGGGCGAGCGCGTCGTTATCAGCCGTGAGGGCGATCGTCTCGTCATCGAGCCAGTGCGCACGAGCA
CAGGATTGCTCAACCTACTTGCGAGCTGGTCTCCCCTCGATGAGGAGTTTCCGGATATCGAGGACGCTCCGGTAAAGCCG
GAGGAAATTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S7Q870

Antitoxin

Source ID Structure
AlphaFold DB A0A822V573

References