Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 564358..564955 Replicon chromosome
Accession NZ_CP048551
Organism Agrobacterium tumefaciens strain Kin002

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FY136_RS02805 Protein ID WP_262516710.1
Coordinates 564638..564955 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FY136_RS02800 Protein ID WP_262516709.1
Coordinates 564358..564657 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY136_RS02775 (FY136_02770) 559430..560428 + 999 WP_206912211.1 asparaginase -
FY136_RS02780 (FY136_02775) 560589..561209 + 621 WP_262516708.1 glutathione S-transferase family protein -
FY136_RS02785 (FY136_02780) 561294..561953 - 660 WP_065115096.1 glutathione S-transferase family protein -
FY136_RS02790 (FY136_02785) 562036..562551 - 516 WP_065115097.1 MarR family transcriptional regulator -
FY136_RS02795 (FY136_02790) 562792..564321 + 1530 WP_065115098.1 MDR family MFS transporter -
FY136_RS02800 (FY136_02795) 564358..564657 - 300 WP_262516709.1 putative addiction module antidote protein Antitoxin
FY136_RS02805 (FY136_02800) 564638..564955 - 318 WP_262516710.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FY136_RS02810 (FY136_02805) 565197..566207 + 1011 WP_262517160.1 ligase-associated DNA damage response exonuclease -
FY136_RS02815 (FY136_02810) 566209..567834 + 1626 WP_262516711.1 cisplatin damage response ATP-dependent DNA ligase -
FY136_RS02820 (FY136_02815) 567962..568927 + 966 WP_110757383.1 alpha/beta fold hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(7-97)

Antitoxin

Uncharacterized protein HI1420

(6-92)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11642.34 Da        Isoelectric Point: 9.5819

>T149607 WP_262516710.1 NZ_CP048551:c564955-564638 [Agrobacterium tumefaciens]
MTNSFEKSVEFDEWLKALKDRTGKVRILHRLTAAEHGNFGDCAPVGGGVSEMRIHCGPGYRVYFTRVGKRIYFLLIGGDK
SSQKWDIKRAIAMAQTIGGDGHDGI

Download         Length: 318 bp

>T149607 NZ_CP064176:c11802-11386 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10842.43 Da        Isoelectric Point: 5.1133

>AT149607 WP_262516709.1 NZ_CP048551:c564657-564358 [Agrobacterium tumefaciens]
MVMTEFSKFDVSDYLDSDEAMIEYLAVAMENENPDVFIAALGAVARARGMSHVADASGLGRESLYKALKLGSKLRYETVQ
RVLHALGFRLAVEKSLNAA

Download         Length: 300 bp

>AT149607 NZ_CP064176:c12029-11799 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References