Detailed information of TA system TA149606

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 374742..375228
• Replicon: chromosome
• Accession: NZ_CP048551
• Organism: Agrobacterium tumefaciens strain Kin002

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: FY136_RS01840
• Protein ID: WP_262516619.1
• Coordinates: 374742..375011 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A822V377
• Locus tag: FY136_RS01845
• Protein ID: WP_003503188.1
• Coordinates: 374995..375228 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY136_RS01810 (FY136_01815)	370330..370773	+	444	WP_262516615.1	hypothetical protein	-
FY136_RS01815 (FY136_01820)	370784..371827	-	1044	WP_262516616.1	YeiH family protein	-
FY136_RS01820 (FY136_01825)	371909..372826	+	918	WP_065114962.1	LysR substrate-binding domain-containing protein	-
FY136_RS01825 (FY136_01830)	373092..373466	-	375	WP_142855368.1	DUF305 domain-containing protein	-
FY136_RS01830 (FY136_01835)	373525..373929	-	405	WP_262516617.1	hypothetical protein	-
FY136_RS01835 (FY136_01840)	373971..374735	-	765	WP_262516618.1	hypothetical protein	-
FY136_RS01840 (FY136_01845)	374742..375011	-	270	WP_262516619.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FY136_RS01845 (FY136_01850)	374995..375228	-	234	WP_003503188.1	DUF6290 family protein	Antitoxin
FY136_RS01850 (FY136_01855)	375386..376909	+	1524	WP_262516620.1	histidine--tRNA ligase	-
FY136_RS01855 (FY136_01860)	376914..377282	+	369	WP_174028905.1	VOC family protein	-
FY136_RS01860 (FY136_01865)	377299..378426	+	1128	WP_174030745.1	ATP phosphoribosyltransferase regulatory subunit	-
FY136_RS01865 (FY136_01870)	378423..379115	+	693	WP_262516621.1	ATP phosphoribosyltransferase	-
FY136_RS01870 (FY136_01875)	379179..379625	-	447	WP_110755375.1	DoxX family protein	-
FY136_RS01875 (FY136_01880)	379779..380198	-	420	WP_065114971.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Protein of unknown function DUF6290 (6-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10312.95 Da
• Isoelectric Point: 10.6555

>T149606 WP_262516619.1 NZ_CP048551:c375011-374742 [Agrobacterium tumefaciens]
MTWRIEFQRAAVKQLGKLAKSDANRIISFLADRIAKDGNPRKTGAALQGSELGNFWRYRVGDYRIICDIQDHKLVVLVVE
IGHRREIYR

Nucleotide

• Length: 270 bp

>T149606 NZ_CP064175:53922-54404 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 9212.31 Da
• Isoelectric Point: 4.6044

>AT149606 WP_003503188.1 NZ_CP048551:c375228-374995 [Agrobacterium tumefaciens]
MSKQTAIRLPDETYERLKALSERTGRTSAYYIREAIEKHIEDMEDLYLAEEATRQRIANKERTYTLEEVMRDLDLEN

Nucleotide

• Length: 234 bp

>AT149606 NZ_CP064175:53668-53934 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A822V377