Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 540740..541334 Replicon chromosome
Accession NZ_CP048543
Organism Agrobacterium tumefaciens strain SJ001

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag FY138_RS02695 Protein ID WP_080865974.1
Coordinates 541020..541334 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FY138_RS02690 Protein ID WP_080865973.1
Coordinates 540740..541039 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY138_RS02665 (FY138_02655) 535928..536926 + 999 WP_060723902.1 asparaginase -
FY138_RS02670 (FY138_02660) 537061..537681 + 621 WP_003508980.1 glutathione S-transferase family protein -
FY138_RS02675 (FY138_02665) 537775..538434 - 660 WP_003508979.1 glutathione S-transferase family protein -
FY138_RS02680 (FY138_02670) 538517..539032 - 516 WP_099085580.1 MarR family transcriptional regulator -
FY138_RS02685 (FY138_02675) 539174..540703 + 1530 WP_060723904.1 MDR family MFS transporter -
FY138_RS02690 (FY138_02680) 540740..541039 - 300 WP_080865973.1 putative addiction module antidote protein Antitoxin
FY138_RS02695 (FY138_02685) 541020..541334 - 315 WP_080865974.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FY138_RS02700 (FY138_02690) 541565..542581 + 1017 WP_163117905.1 ligase-associated DNA damage response exonuclease -
FY138_RS02705 (FY138_02695) 542583..544208 + 1626 WP_099085579.1 cisplatin damage response ATP-dependent DNA ligase -
FY138_RS02710 (FY138_02700) 544383..545348 + 966 WP_020813204.1 alpha/beta fold hydrolase -
FY138_RS02715 (FY138_02705) 545387..546169 - 783 WP_003508963.1 glycosyltransferase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-95)

Antitoxin

Uncharacterized protein HI1420

(6-97)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11772.48 Da        Isoelectric Point: 10.3857

>T149605 WP_080865974.1 NZ_CP048543:c541334-541020 [Agrobacterium tumefaciens]
MNSFQKSAEFDEWLKVLKDRAGKVRILHRLTAAEHGNFGDCAPVGEGVSEMRIHFGPGYRVYFTRVGKRVYFLLVGGDKS
SQRRDIKRAIEMAQTIGRDGRDGI

Download         Length: 315 bp

>T149605 NZ_CP064174:5270976-5271359 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10765.29 Da        Isoelectric Point: 4.8307

>AT149605 WP_080865973.1 NZ_CP048543:c541039-540740 [Agrobacterium tumefaciens]
MAVTEFSKFDVSDYLDSDEAMIEFLAIAMEDENPDVFIGALGAVAKARGMSHIADASGLGRESLYKALRPGSKLRYETVQ
RVLHALGFRLAVEKSLNAA

Download         Length: 300 bp

>AT149605 NZ_CP064174:5270734-5270976 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References