Detailed information of TA system TA149602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 460546..461090
• Replicon: chromosome
• Accession: NZ_CP048540
• Organism: Agrobacterium tumefaciens strain SJ002

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FY139_RS12195
• Protein ID: WP_173992172.1
• Coordinates: 460800..461090 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A822V4A8
• Locus tag: FY139_RS12190
• Protein ID: WP_003509084.1
• Coordinates: 460546..460797 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY139_RS12170 (FY139_12130)	456307..456987	+	681	WP_003509096.1	GntR family transcriptional regulator	-
FY139_RS12175 (FY139_12135)	457033..457509	+	477	WP_099085593.1	DUF1284 domain-containing protein	-
FY139_RS12180 (FY139_12140)	457685..458785	-	1101	WP_099085592.1	hypothetical protein	-
FY139_RS12185 (FY139_12145)	459022..460167	+	1146	WP_087743499.1	site-specific DNA-methyltransferase	-
FY139_RS12190 (FY139_12150)	460546..460797	+	252	WP_003509084.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FY139_RS12195 (FY139_12155)	460800..461090	+	291	WP_173992172.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FY139_RS12200 (FY139_12160)	461132..461743	-	612	WP_087743505.1	HAD family phosphatase	-
FY139_RS12205 (FY139_12165)	461740..462852	-	1113	WP_099085591.1	A/G-specific adenine glycosylase	-
FY139_RS12210 (FY139_12170)	462980..463444	+	465	WP_020812858.1	hypothetical protein	-
FY139_RS12215 (FY139_12175)	463472..463993	+	522	WP_003509079.1	DUF721 domain-containing protein	-
FY139_RS12220 (FY139_12180)	464122..464802	+	681	WP_003509078.1	DsbA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (12-70)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11225.88 Da
• Isoelectric Point: 6.2182

>T149602 WP_173992172.1 NZ_CP048540:460800-461090 [Agrobacterium tumefaciens]
VGFRLSLLAEEDVIRIAEEGIAIFGLAQAQKYHRELYEIFELISLNPRMARERHELLPPLRIHRFRTHLVVYGVGADDDV
LIVRVRHAHEDWVNES

Nucleotide

• Length: 291 bp

>T149602 NZ_CP064174:c4455351-4454866 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9339.55 Da
• Isoelectric Point: 9.7317

>AT149602 WP_003509084.1 NZ_CP048540:460546-460797 [Agrobacterium tumefaciens]
MATMNISLPAPMKEWVEAQSRTGRYSNASDYVRDLIRKDQERGEKIAAMQHFVDEGLQSGAGHRSQQALFAEAEARSMKR
KIG

Nucleotide

• Length: 252 bp

>AT149602 NZ_CP064174:c4455641-4455348 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A822V4A8